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Study on secondary metabolites of Penicillium expansum GY618 and their tyrosinase inhibitory activities
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Fei-yu YIN1, Sheng LIANG2, Qian-heng ZHU3, Feng-hua YUAN2, Hao HUANG3, Hui-ling WEN3, *
Acta Pharmaceutica Sinica | 2025, 60(2) : 427 - 433
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Acta Pharmaceutica Sinica | 2025, 60(2): 427-433
• Original Articles •
Study on secondary metabolites of Penicillium expansum GY618 and their tyrosinase inhibitory activities
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Fei-yu YIN1, Sheng LIANG2, Qian-heng ZHU3, Feng-hua YUAN2, Hao HUANG3, Hui-ling WEN3, *
Affiliations
  • 1. School of Rehabilitation, Gannan Medical University, Ganzhou 341000, China
  • 2. School of Basic Medicine, Gannan Medical University, Ganzhou 341000, China
  • 3. School of Pharmacy, Gannan Medical University, Ganzhou 341000, China
Published: 2025-02-12 doi: 10.16438/j.0513-4870.2024-0845
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Twelve compounds were isolated from the rice fermentation extracts of Penicillium expansum GY618 by silica column chromatography, Sephadex gel column chromatography, ODS column chromatography and semi preparative HPLC methods. They were determined as 11-hydroxyl-penicitrinone F (1), penicitrinone F (2), betulin (3), erythrodiol (4), ergosterol (5), ergost-5α, 8α-epidioxy-6, 22-dien-3β-ol (6), (5α, 8α-epidioxy-(22E, 24R)-ergosta-6, 9(11), 22-trien-3β-ol) (7), 5α, 8α-epidioxy-(22E, 24R)-23-methylergosta-6, 22-dien-3β-ol (8), 5α, 8α-epidioxy- 23, 24(R)-dimethylcholesta-6, 9(11), 22-trien-3β-ol (9), dankasterone A (10), (17R)-4-hydroxy-17-methylincisterol (11) and ergosta-4, 6, 8(14), 22-tetraen-3-one (12), through mass spectrometer, nuclear magnetic resonance (NMR) and comparison with the literature. Compound 1 was a new compound and compounds 2-4, 6-12 were isolated from Penicillium expansum fungus for the first time. The tyrosinase inhibitory activity experiment showed that compounds 1, 3 and 12 showed certain inhibitory activity against tyrosinase with IC50 values of (75 ± 9), (69 ± 8) and (64 ± 2) μmol·L-1, respectively. The IC50 of other compounds were all greater than 100 μmol·L-1, while IC50 of the positive control kojic acid was (46 ± 4) μmol·L-1.

Penicillium expansum  /  rice fermentation  /  secondary metabolite  /  structural identification  /  tyrosinase inhibitory activity
Fei-yu YIN, Sheng LIANG, Qian-heng ZHU, Feng-hua YUAN, Hao HUANG, Hui-ling WEN. Study on secondary metabolites of Penicillium expansum GY618 and their tyrosinase inhibitory activities[J]. Acta Pharmaceutica Sinica, 2025 , 60 (2) : 427 -433 . DOI: 10.16438/j.0513-4870.2024-0845
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Year 2025 volume 60 Issue 2
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Article Info
doi: 10.16438/j.0513-4870.2024-0845
  • Receive Date：2024-08-30
  • Online Date：2025-11-07
  • Published：2025-02-12
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History
  • Received：2024-08-30
  • Revised：2024-12-05
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Affiliations
    1. School of Rehabilitation, Gannan Medical University, Ganzhou 341000, China
    2. School of Basic Medicine, Gannan Medical University, Ganzhou 341000, China
    3. School of Pharmacy, Gannan Medical University, Ganzhou 341000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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