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Chemical consitituents and hypoglycemic activity of Sophora tonkinensis
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Xiao-yun YAN1, 2, Ling-feng QIN2, Rui ZHANG2, Ya-nan YANG2, Jin-ying TIAN2, Fei YE2, Xu ZHANG2, *, Pei-cheng ZHANG2, *, Guo-cheng WANG1, *
Acta Pharmaceutica Sinica | 2024, 59(11) : 3135 - 3140
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Acta Pharmaceutica Sinica | 2024, 59(11): 3135-3140
Chemical consitituents and hypoglycemic activity of Sophora tonkinensis
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Xiao-yun YAN1, 2, Ling-feng QIN2, Rui ZHANG2, Ya-nan YANG2, Jin-ying TIAN2, Fei YE2, Xu ZHANG2, *, Pei-cheng ZHANG2, *, Guo-cheng WANG1, *
Affiliations
  • 1. College of Pharmacy, Inner Mongolia Medical University, Hohhot 010059, China
  • 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2024-11-12 doi: 10.16438/j.0513-4870.2024-0549
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Eleven compounds were isolated from the ethyl acetate fraction of the 95% aqueous ethanol extract of the roots of Sophora tonkinensis by silica gel, ODS, Sephadex LH-20 column chromatography, and semi-preparative RP-HPLC. Their structures were identified as 7-hydroxy-8-isopentenylchromone (1), furo[2, 3-f]-1, 3-benzodioxole-7-carboxylic acid (2), 6-[3-(2′, 4′-dihydroxyphenyl)acryloyl]-7-hydroxy-2, 2-dimethyl-8-(3-methyl-2-butenyl)-2H-benzopyran (3), flemichapparin B (4), tectorigenin (5), genistein (6), 6-hydroxy-1, 3-benzodioxole-5-carboxylic acid (7), vanillic acid (8), protocatechuic acid (9), 2, 4-dihydroxybenzoic acid (10), and p-hydroxybenzoic acid (11) through extensive spectroscopic data (IR, UV, HR-ESI-MS, and NMR spectra). Among them, compounds 1 and 2 were new compounds. In addition, compound 3 showed significant α-glucosidase and protein tyrosine phosphatase-1B (PTP1B) inhibitory activities with IC50 values of 5.595 and 0.320 μmol·L-1, respectively.

Sophora tonkinensis  /  chemical constituent  /  chromone  /  benzofuran  /  α-glucosidase inhibition  /  protein tyrosine phosphatase-1B inhibition
Xiao-yun YAN, Ling-feng QIN, Rui ZHANG, Ya-nan YANG, Jin-ying TIAN, Fei YE, Xu ZHANG, Pei-cheng ZHANG, Guo-cheng WANG. Chemical consitituents and hypoglycemic activity of Sophora tonkinensis[J]. Acta Pharmaceutica Sinica, 2024 , 59 (11) : 3135 -3140 . DOI: 10.16438/j.0513-4870.2024-0549
Year 2024 volume 59 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2024-0549
  • Receive Date:2024-06-11
  • Online Date:2025-11-24
  • Published:2024-11-12
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  • Received:2024-06-11
  • Revised:2024-07-08
Affiliations
    1. College of Pharmacy, Inner Mongolia Medical University, Hohhot 010059, China
    2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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