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Research progress on the structural modification of isosteviol and the biological activities of its derivatives
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Li-jun ZHAO1, You-fu YANG1, Tong-sheng WANG1, Yan-li ZHANG1, 2, *, Ya WU1, 2, *
Acta Pharmaceutica Sinica | 2025, 60(1) : 22 - 36
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Acta Pharmaceutica Sinica | 2025, 60(1): 22-36
• Reviews •
Research progress on the structural modification of isosteviol and the biological activities of its derivatives
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Li-jun ZHAO1, You-fu YANG1, Tong-sheng WANG1, Yan-li ZHANG1, 2, *, Ya WU1, 2, *
Affiliations
  • 1. College of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Published: 2025-01-12 doi: 10.16438/j.0513-4870.2024-0491
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Isosteviol is a tetracyclic diterpenoid compound obtained by hydrolysis of natural stevia glycoside under acidic conditions. It has many pharmacological activities, such as anti-tumor, hypoglycemic, anti-inflammatory and antibacterial. Due to its low water solubility, low activity and low bioavailability, isosteviol has poor performance. In order to overcome these shortcomings, scholars have obtained a large number of isosteviol derivatives with novel structures and excellent activity. In this paper, we review the recent progress in the research on the structure modification, biological activity, structure-activity relationship and microbial transformation of isosteviol, in order to provide a reference for the development of new drugs of isosteviol and its derivatives.

isosteviol  /  derivative  /  structural modification  /  microbial transformation  /  biological activity  /  structure-activity relationship
Li-jun ZHAO, You-fu YANG, Tong-sheng WANG, Yan-li ZHANG, Ya WU. Research progress on the structural modification of isosteviol and the biological activities of its derivatives[J]. Acta Pharmaceutica Sinica, 2025 , 60 (1) : 22 -36 . DOI: 10.16438/j.0513-4870.2024-0491
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Year 2025 volume 60 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2024-0491
  • Receive Date：2024-05-23
  • Online Date：2025-11-07
  • Published：2025-01-12
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History
  • Received：2024-05-23
  • Revised：2024-08-01
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Affiliations
    1. College of Medicine, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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