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A new model for screening active ingredients in traditional Chinese medicine based on the interactions between gut microorganisms and G protein-coupled receptor
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Chang-min LIU1, Yi-xuan ZHENG1, Jing-sheng YU1, 2, Hui WANG1, Shi-lin CHEN1, Chi SONG1, *
Acta Pharmaceutica Sinica | 2024, 59(11) : 3042 - 3056
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Acta Pharmaceutica Sinica | 2024, 59(11): 3042-3056
A new model for screening active ingredients in traditional Chinese medicine based on the interactions between gut microorganisms and G protein-coupled receptor
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Chang-min LIU1, Yi-xuan ZHENG1, Jing-sheng YU1, 2, Hui WANG1, Shi-lin CHEN1, Chi SONG1, *
Affiliations
  • 1. Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
Published: 2024-11-12 doi: 10.16438/j.0513-4870.2024-0333
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Gut microbiome and their metabolites are closely related to human diseases, which influence the development of diseases by interacting with receptors. G protein-coupled receptor (GPCR) is a receptor superfamily that exists on the surface of cell membrane, which is involved in a wide range of human physiological activities. GPCR is currently considered as important drug targets. Traditional Chinese medicines (TCM) are characterized by multi-components, multi-targets, and multi-pathways. More and more studies have demonstrated that TCM can ultimately intervene in diseases by modulating gut microbiome and their metabolites, affecting their interactions with GPCR. This review discusses the status of gut microbiome and human diseases, the interactions of gut microbiome and their metabolites with GPCR, and the status of GPCR drug development. Based on the above contents, a new model of "TCM-gut microbiome panel-GPCR-disease" is proposed. The interactions between active ingredients of TCM, gut microbiome panel, and GPCR and their effects on disease are elucidated through multi-omics techniques. This review will provide new ideas for analyzing the pharmacological mechanism of TCM efficacy and searching for new targets of TCM.

gut microbiome  /  G protein-coupled receptor  /  disease  /  traditional Chinese medicine  /  drug screening
Chang-min LIU, Yi-xuan ZHENG, Jing-sheng YU, Hui WANG, Shi-lin CHEN, Chi SONG. A new model for screening active ingredients in traditional Chinese medicine based on the interactions between gut microorganisms and G protein-coupled receptor[J]. Acta Pharmaceutica Sinica, 2024 , 59 (11) : 3042 -3056 . DOI: 10.16438/j.0513-4870.2024-0333
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Year 2024 volume 59 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2024-0333
  • Receive Date：2024-04-28
  • Online Date：2025-11-24
  • Published：2024-11-12
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  • Received：2024-04-28
  • Revised：2024-07-29
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Affiliations
    1. Institute of Herbgenomics, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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