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Advances in research of dual inhibitors targeting Janus kinase and histone deacetylase
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Jing SHEN1, Wei-jie HU2, Guo-qiang DONG1, Chun-quan SHENG1, *, Ya-hui HUANG1, *
Acta Pharmaceutica Sinica | 2024, 59(11) : 3057 - 3073
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Acta Pharmaceutica Sinica | 2024, 59(11): 3057-3073
Advances in research of dual inhibitors targeting Janus kinase and histone deacetylase
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Jing SHEN1, Wei-jie HU2, Guo-qiang DONG1, Chun-quan SHENG1, *, Ya-hui HUANG1, *
Affiliations
  • 1. The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China
  • 2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
Published: 2024-11-12 doi: 10.16438/j.0513-4870.2024-0263
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Janus kinase (JAK) and histone deacetylase (HDAC) referred to as crucial targets in autoimmune diseases and cancers have achieved quite success in the treatment of these diseases. Until now, several JAK and HDAC inhibitors have been approved. Recently, developing single multi-targeting inhibitors including JAK/HDAC dual inhibitors based on network pharmacology has made significant progress in improving therapeutic efficacy, reducing toxic and side effects, and overcoming drug resistance. In this review, we summarize novel JAK/HDAC dual inhibitors as well as JAK/HDAC-based triple-targeting inhibitors, in order to provide reference for the discovery of novel JAK/HDAC dual inhibitor.

Janus kinase  /  histone deacetylase  /  dual-target inhibitor  /  structure activity relationship  /  pharmacophore
Jing SHEN, Wei-jie HU, Guo-qiang DONG, Chun-quan SHENG, Ya-hui HUANG. Advances in research of dual inhibitors targeting Janus kinase and histone deacetylase[J]. Acta Pharmaceutica Sinica, 2024 , 59 (11) : 3057 -3073 . DOI: 10.16438/j.0513-4870.2024-0263
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Year 2024 volume 59 Issue 11
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Article Info
doi: 10.16438/j.0513-4870.2024-0263
  • Receive Date：2024-03-02
  • Online Date：2025-11-24
  • Published：2024-11-12
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History
  • Received：2024-03-02
  • Revised：2024-08-14
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Affiliations
    1. The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China
    2. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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