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Advances in 4D printing technology in medicine
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Jia-jing ZHAO1, Xiao-xuan HONG2, Xiao-lu HAN2, Cong-hui LI2, Hui ZHANG2, Nan LIU2, Fan YANG3, *, Zeng-ming WANG2, *, Ai-ping ZHENG2
Acta Pharmaceutica Sinica | 2025, 60(8) : 2475 - 2485
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Acta Pharmaceutica Sinica | 2025, 60(8): 2475-2485
• Reviews •
Advances in 4D printing technology in medicine
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Jia-jing ZHAO1, Xiao-xuan HONG2, Xiao-lu HAN2, Cong-hui LI2, Hui ZHANG2, Nan LIU2, Fan YANG3, *, Zeng-ming WANG2, *, Ai-ping ZHENG2
Affiliations
  • 1College of Pharmacy, Yanbian University, Yanji 133002, China
  • 2Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
  • 3Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou 510006, China
Published: 2025-08-12 doi: 10.16438/j.0513-4870.2024-0194
Outline
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4D printing technology represents a revolutionary breakthrough in the field of additive manufacturing. It not only inherits the spatial construction capabilities of 3D printing but also introduces the dimension of time, endowing printed objects with dynamic "life". This technology uses smart responsive materials that allow printed objects to change their shape, properties, or functions in response to specific environmental stimuli, such as temperature, magnetic fields, or light changes, as programmed in advance. This has shown great potential and application prospects in the fields of medical research and clinical applications. In this article, we first explore the smart responsive materials that enable 4D printing and introduce their unique physical and chemical properties and functions. Secondly, we review the innovative applications of these smart materials in the medical fields of tissue engineering, regenerative medicine, and drug delivery. Finally, we discuss the challenges faced by 4D printing technology in practical applications and look forward to the future development direction of the technology and its broader application potential in various fields.

4D printing technology  /  smart responsive material  /  morphological change  /  medical application  /  prospect and challenge
赵佳婧, 洪晓轩, 韩晓璐, 李聪慧, 张慧, 刘楠, 杨帆, 王增明, 郑爱萍. 4D打印技术在医药领域中的研究进展. 药学学报, 2025 , 60 (8) : 2475 -2485 . DOI: 10.16438/j.0513-4870.2024-0194
Jia-jing ZHAO, Xiao-xuan HONG, Xiao-lu HAN, Cong-hui LI, Hui ZHANG, Nan LIU, Fan YANG, Zeng-ming WANG, Ai-ping ZHENG. Advances in 4D printing technology in medicine[J]. Acta Pharmaceutica Sinica, 2025 , 60 (8) : 2475 -2485 . DOI: 10.16438/j.0513-4870.2024-0194
Year 2025 volume 60 Issue 8
239
124
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Article Info
doi: 10.16438/j.0513-4870.2024-0194
  • Receive Date:2024-03-06
  • Online Date:2026-09-20
  • Published:2025-08-12
Article Data
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History
  • Received:2024-03-06
  • Revised:2024-11-05
Affiliations
    1College of Pharmacy, Yanbian University, Yanji 133002, China
    2Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
    3Guangdong Provincial Key Laboratory of Advanced Drug Delivery, Guangdong Provincial Engineering Center of Topical Precise Drug Delivery System, Teaching and Experimental Center, Guangdong Pharmaceutical University, Guangzhou 510006, China
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表12种不同金属材料的力学参数
科
Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)
属
Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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