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Four new dammarane-type triterpenoid saponins from Gynostemma pentaphyllum (Thunb.) Makino
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Guang YANG1, 2, Hai-zhen LIANG2, Jie ZHANG2, Xiao-juan CHEN2, Bao-lin GUO3, Bai-ping MA1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(8) : 2288 - 2294
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Acta Pharmaceutica Sinica | 2024, 59(8): 2288-2294
Four new dammarane-type triterpenoid saponins from Gynostemma pentaphyllum (Thunb.) Makino
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Guang YANG1, 2, Hai-zhen LIANG2, Jie ZHANG2, Xiao-juan CHEN2, Bao-lin GUO3, Bai-ping MA1, 2, *
Affiliations
  • 1. Guangdong Pharmaceutical University, Guangzhou 510006, China
  • 2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
  • 3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
Published: 2024-08-12 doi: 10.16438/j.0513-4870.2024-0119
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Damarane-type triterpene saponins are the main active ingredients in Gynostemma pentaphyllum (Thunb.) Makino. By using D101 macroporous adsorption resin and silica gel open-columns, C18 medium-pressure column chromatography, and preparative high performance liquid chromatography, we isolated four compounds from the leaves of G. pentaphyllum planted in Guangxi Zhuang Autonomous Region. Their structures were determined by comprehensive analyses of MS, NMR data and circular dichroism spectroscopy and identified as (3β, 12β)-dihydroxy-25-peroxyhydrohydrodammarane-20, 23-diene-3-O-[β-D-glucopyranosyl(1→2)]-β-D-glucopyranoside (1), (3β, 12β, 24S)-trihydroxydammarane-20, 25-diene-3-O-[β-D-glucopyranosyl(1→2)]-β-D-glucopyranoside (2), (3β, 20α)-dihydroxy-24-en-12β, 22S-epoxydammarane-3-O-[β-D-glucopyranosyl(1→2)]-β-D-glucopyranoside (3), (3β, 12β, 20S)-trihydroxydammarane-24-en-3-O-[6-O-acetyl-β-D-glucopyranosyl(1→2)-β-D-glucopyranosyl]-20-O-β-D-xylopyranosyl(1→3)-α-L-rhamnopyranosyl (1→6)-β-D-glucopyranoside (4). Compounds 1-4   are new dammarane-type triterpene saponins.

Cucurbitaceae  /  Gynostemma pentaphyllum  /  triterpenoid saponin  /  isolation  /  structural elucidation
Guang YANG, Hai-zhen LIANG, Jie ZHANG, Xiao-juan CHEN, Bao-lin GUO, Bai-ping MA. Four new dammarane-type triterpenoid saponins from Gynostemma pentaphyllum (Thunb.) Makino[J]. Acta Pharmaceutica Sinica, 2024 , 59 (8) : 2288 -2294 . DOI: 10.16438/j.0513-4870.2024-0119
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Year 2024 volume 59 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2024-0119
  • Receive Date：2024-02-05
  • Online Date：2025-11-26
  • Published：2024-08-12
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History
  • Received：2024-02-05
  • Revised：2024-04-30
Affiliations
    1. Guangdong Pharmaceutical University, Guangzhou 510006, China
    2. Institute of Radiation Medicine, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
    3. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100193, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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