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Advances in DNA origami intelligent drug delivery systems
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Zeng-lin YIN1, 2, Xi-wei WANG2, Jin-jing CHE2, Nan LIU2, Hui ZHANG2, Zeng-ming WANG2, Jian-chun LI1, *, Ai-ping ZHENG2, *
Acta Pharmaceutica Sinica | 2024, 59(10) : 2741 - 2750
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Acta Pharmaceutica Sinica | 2024, 59(10): 2741-2750
Advances in DNA origami intelligent drug delivery systems
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Zeng-lin YIN1, 2, Xi-wei WANG2, Jin-jing CHE2, Nan LIU2, Hui ZHANG2, Zeng-ming WANG2, Jian-chun LI1, *, Ai-ping ZHENG2, *
Affiliations
  • 1. School of Pharmacy, Bengbu Medical University, Bengbu 233030, China
  • 2. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
Published: 2024-10-12 doi: 10.16438/j.0513-4870.2024-0111
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DNA origami is a powerful technique for generating nanostructures with dynamic properties and intelligent controllability. The precise geometric shapes, high programmability, and excellent biocompatibility make DNA origami nanostructures an emerging drug delivery vehicle. The shape, size of the carrier material, as well as the loading and release of drugs are important factors affecting the bioavailability of drugs. This paper focuses on the controllable design of DNA origami nanostructures, efficient drug loading, and intelligent drug release. It summarizes the cutting-edge applications of DNA origami technology in biomedicine, and discusses areas where researchers can contribute to further advancing the clinical application of DNA origami carriers.

DNA origami  /  programmability  /  drug delivery  /  controllable design  /  biomedicine
Zeng-lin YIN, Xi-wei WANG, Jin-jing CHE, Nan LIU, Hui ZHANG, Zeng-ming WANG, Jian-chun LI, Ai-ping ZHENG. Advances in DNA origami intelligent drug delivery systems[J]. Acta Pharmaceutica Sinica, 2024 , 59 (10) : 2741 -2750 . DOI: 10.16438/j.0513-4870.2024-0111
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Article Info
doi: 10.16438/j.0513-4870.2024-0111
  • Receive Date：2024-02-02
  • Online Date：2025-11-24
  • Published：2024-10-12
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History
  • Received：2024-02-02
  • Revised：2024-07-09
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Affiliations
    1. School of Pharmacy, Bengbu Medical University, Bengbu 233030, China
    2. State Key Laboratory of National Security Specially Needed Medicines, Academy of Military Medical Sciences, Beijing 100850, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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