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Research progress of nanomedical drug delivery system based on aerobic glycolytic regulation for tumor therapy
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Yi-jing LI1, Sheng-nan HUANG2, 3, *, Zi-ang WANG1, Wei-wei ZHI1, Xia-li ZHU1, *
Acta Pharmaceutica Sinica | 2024, 59(9) : 2509 - 2518
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Acta Pharmaceutica Sinica | 2024, 59(9): 2509-2518
Research progress of nanomedical drug delivery system based on aerobic glycolytic regulation for tumor therapy
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Yi-jing LI1, Sheng-nan HUANG2, 3, *, Zi-ang WANG1, Wei-wei ZHI1, Xia-li ZHU1, *
Affiliations
  • 1. Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 3. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China
Published: 2024-09-12 doi: 10.16438/j.0513-4870.2024-0068
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Tumor is one of the serious problems threatening human health. There are some limitations in the delivery of commonly used tumor therapy technologies, and the therapeutic effect is not satisfactory, so new anti-tumor strategies need to be developed. The process of tumor cells using glycolysis to produce energy under aerobic conditions is called aerobic glycolysis, which is closely related to tumor growth, proliferation and metastasis, and can provide a new target spot for tumor treatment. Nano drug delivery system has been widely used in targeted tumor therapy because of its advantages of targeted drug delivery, improved anti-tumor efficacy and reduced toxic side effects. Numerous studies have shown that more and more nano drug delivery systems regulates aerobic glycolytic metabolism by targeting to potential targets such as signaling factors or reaction products of aerobic glycolytic process in tumors, and therefore enhance the anti-tumor effect. This paper reviews the application of nano drug delivery system in regulating tumor aerobic glycolysis, and provides theoretical references for realizing efficient targeted tumor therapy.

aerobic glycolysis  /  nano drug delivery system  /  tumor therapy  /  combined therapy
Yi-jing LI, Sheng-nan HUANG, Zi-ang WANG, Wei-wei ZHI, Xia-li ZHU. Research progress of nanomedical drug delivery system based on aerobic glycolytic regulation for tumor therapy[J]. Acta Pharmaceutica Sinica, 2024 , 59 (9) : 2509 -2518 . DOI: 10.16438/j.0513-4870.2024-0068
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Article Info
doi: 10.16438/j.0513-4870.2024-0068
  • Receive Date：2024-01-22
  • Online Date：2025-11-24
  • Published：2024-09-12
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History
  • Received：2024-01-22
  • Revised：2024-06-11
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Affiliations
    1. Pharmacy College, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. Academy of Chinese Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450046, China
    3. Collaborative Innovation Center of Research and Development on the Whole Industry Chain of Yu-Yao Henan Province, Henan University of Chinese Medicine, Zhengzhou 450046, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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