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Correlation of CD200-CD200R axis and diseases and its research progress
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Han XU1, Yu-xin BI2, Gui-xia LI2, Jian LI2, Liu-li WANG2, Rui-jia HAO2, Xue-min ZHENG2, Rui-jing HUANG2, Jin HAN2, Fei LI1, *, Gen-bei WANG2, *
Acta Pharmaceutica Sinica | 2024, 59(4) : 822 - 830
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Acta Pharmaceutica Sinica | 2024, 59(4): 822-830
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Correlation of CD200-CD200R axis and diseases and its research progress
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Han XU1, Yu-xin BI2, Gui-xia LI2, Jian LI2, Liu-li WANG2, Rui-jia HAO2, Xue-min ZHENG2, Rui-jing HUANG2, Jin HAN2, Fei LI1, *, Gen-bei WANG2, *
Affiliations
  • 1. China Pharmaceutical University, Nanjing 211198, China
  • 2. TASLY Pharmaceutical Group Co., Ltd., Tianjin 300000, China
Published: 2024-04-12 doi: 10.16438/j.0513-4870.2023-1372
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CD200 and its receptor CD200R constitute an endogenous inhibitory signal. The binding of CD200 and CD200R can regulate the immune response to pathogenic stimuli, which has received much attention in recent years. It has been found that CD200-CD200R is involved in the regulation of many kinds of pathological inflammation, including autoimmune diseases, cardiac cerebrovascular disease, infection and tumor. This paper reviews the protein structure, distribution, expression, biological function of CD200-CD200R and the correlation with diseases, and analyses the current status and development ideas of CD200-CD200R as drug targets. It aims to provide theoretical support for new drug research and development based on this target.

CD200  /  CD200R  /  disease  /  targeted drug  /  immune checkpoint
Han XU, Yu-xin BI, Gui-xia LI, Jian LI, Liu-li WANG, Rui-jia HAO, Xue-min ZHENG, Rui-jing HUANG, Jin HAN, Fei LI, Gen-bei WANG. Correlation of CD200-CD200R axis and diseases and its research progress[J]. Acta Pharmaceutica Sinica, 2024 , 59 (4) : 822 -830 . DOI: 10.16438/j.0513-4870.2023-1372
Year 2024 volume 59 Issue 4
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doi: 10.16438/j.0513-4870.2023-1372
  • Receive Date:2023-12-06
  • Online Date:2025-11-28
  • Published:2024-04-12
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  • Received:2023-12-06
  • Revised:2024-01-17
Affiliations
    1. China Pharmaceutical University, Nanjing 211198, China
    2. TASLY Pharmaceutical Group Co., Ltd., Tianjin 300000, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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