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Vasorelaxant activity and mechanism of essential oil from Curcuma longa L.
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Bo-yu LI1, 2, Jin-feng CHEN1, 2, Ting CUI1, 2, Cheng PENG1, Fei LIU1, 2, *, Liang XIONG1, 2, 3, *
Acta Pharmaceutica Sinica | 2024, 59(6) : 1691 - 1697
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Acta Pharmaceutica Sinica | 2024, 59(6): 1691-1697
• Original Articles •
Vasorelaxant activity and mechanism of essential oil from Curcuma longa L.
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Bo-yu LI1, 2, Jin-feng CHEN1, 2, Ting CUI1, 2, Cheng PENG1, Fei LIU1, 2, *, Liang XIONG1, 2, 3, *
Affiliations
  • 1. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 2. Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
  • 3. School of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
Published: 2024-06-12 doi: 10.16438/j.0513-4870.2023-1363
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The essential oil from Curcuma longa L. (CLEO) was extracted by steam distillation. In this study, vasorelaxant activity and mechanism of CLEO was explored. Firstly, the experimental results of isolated rat thoracic aorta ring showed that the CLEO had vasorelaxant activity. By removing the endothelium of aorta ring and pre-incubating inhibitor of endothelial nitric oxide synthase (eNOS), it was found that the vasorelaxant activity of CLEO was endothelium-dependent and related to eNOS. By human umbilical vein endothelial cells (HUVECs) model, it was found that the CLEO could promote the production of nitric oxide (NO) in HUVECs, further indicating that the vasorelaxant activity of CLEO was related to eNOS. The results of Western blot showed that CLEO could up-regulate the phosphorylation levels of phosphatidylinositol 3-kinase (PI3K), protein kinase B (Akt) and eNOS. In summary, the CLEO has vasorelaxant activity, and its mechanism is related to activating the endothelial PI3K/Akt/eNOS pathway. All animal experiments in this paper were approved by the Committee of Laboratory Animal Welfare Ethics of Chengdu University of Traditional Chinese Medicine (approval No. 2020-04).

Curcuma longa L.  /  essential oil  /  vasodilation  /  endothelium-dependent  /  PI3K/Akt/eNOS
Bo-yu LI, Jin-feng CHEN, Ting CUI, Cheng PENG, Fei LIU, Liang XIONG. Vasorelaxant activity and mechanism of essential oil from Curcuma longa L.[J]. Acta Pharmaceutica Sinica, 2024 , 59 (6) : 1691 -1697 . DOI: 10.16438/j.0513-4870.2023-1363
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Article Info
doi: 10.16438/j.0513-4870.2023-1363
  • Receive Date：2023-12-05
  • Online Date：2025-11-26
  • Published：2024-06-12
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History
  • Received：2023-12-05
  • Revised：2024-04-27
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Affiliations
    1. State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    2. Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
    3. School of Medical Technology, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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