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New advances in stroke therapy targeting the CREB signaling pathway and the potential for herbal interventions
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Cui-cui CHENG1, Yu-juan LIANG1, Xing LI2, Ming LÜ1, *, Yan ZHU1, *
Acta Pharmaceutica Sinica | 2024, 59(6) : 1538 - 1545
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Acta Pharmaceutica Sinica | 2024, 59(6): 1538-1545
• Reviews •
New advances in stroke therapy targeting the CREB signaling pathway and the potential for herbal interventions
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Cui-cui CHENG1, Yu-juan LIANG1, Xing LI2, Ming LÜ1, *, Yan ZHU1, *
Affiliations
  • 1. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
  • 2. Guizhou Bailing Group Pharmaceutical Co., Ltd., Guiyang 550000, China
Published: 2024-06-12 doi: 10.16438/j.0513-4870.2023-1308
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cAMP response element binding protein (CREB) is an eukaryotic intranuclear protein widely expressed in a variety of organs, and its activation increases the transcriptional activity of downstream genes and promotes the expression of related genes. The neuronal function of CREB is related to many intracellular processes, such as proliferation, differentiation, survival, long-term synaptic potentials, neurogenesis and neuronal plasticity. Increasing evidence has demonstrated that CREB plays an important role in the stroke development and therefore, it may serve as a potential target for stroke therapy. Since some herbal medicines as well as their active ingredients regulate the CREB signaling, this article will summarize the role of CREB signaling pathway in stroke pathophysiology. The research progress of traditional Chinese medicine and its active ingredients modulating CREB activity will also be discussed, with the aim of providing the basis and reference for the future research and development of natural medicines against stroke.

stroke  /  cAMP response element binding protein  /  synaptic plasticity  /  apoptosis  /  traditional Chinese medicine
Cui-cui CHENG, Yu-juan LIANG, Xing LI, Ming LÜ, Yan ZHU. New advances in stroke therapy targeting the CREB signaling pathway and the potential for herbal interventions[J]. Acta Pharmaceutica Sinica, 2024 , 59 (6) : 1538 -1545 . DOI: 10.16438/j.0513-4870.2023-1308
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Article Info
doi: 10.16438/j.0513-4870.2023-1308
  • Receive Date：2023-11-20
  • Online Date：2025-11-26
  • Published：2024-06-12
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History
  • Received：2023-11-20
  • Revised：2023-12-19
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Affiliations
    1. State Key Laboratory of Component-based Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China
    2. Guizhou Bailing Group Pharmaceutical Co., Ltd., Guiyang 550000, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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