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Naphthoquinone and carboxylic acid derivatives from the fungus Pleosporales sp.
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Si-yuan QI, Li-hua ZHANG, Yi-nan HAO, You-cai HU, Jian BAI*
Acta Pharmaceutica Sinica | 2024, 59(5) : 1327 - 1333
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Acta Pharmaceutica Sinica | 2024, 59(5): 1327-1333
• Original Articles •
Naphthoquinone and carboxylic acid derivatives from the fungus Pleosporales sp.
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Si-yuan QI, Li-hua ZHANG, Yi-nan HAO, You-cai HU, Jian BAI*
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  • Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2024-05-12 doi: 10.16438/j.0513-4870.2023-1269
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Three new compounds, including a naphthoquinone, a reduced naphthoquinone derivative naphthalenone, and a tricarboxylic acid, along with five known naphthalenone derivatives were isolated from ethyl acetate extract of rice fermentation products of the fungus Pleosporales sp. by multiple column chromatographic methods, including Sephadex LH-20 gel column chromatography, silica gel column chromatography, reversed-phase HPLC, and chiral chromatography. Their structures were elucidated by MS, NMR, and specific rotation spectroscopic analyses as well as ECD calculations. Three novel compounds were named as pleospathone A (1), pleospathone B (2), and pleosporalic acid A (3). Five known compounds were separately identified as (3S, 4R)-3,4,8-trihydroxy-6-methyl-3,4-dihydronaphthalen-1(2H)-one (4), (4R)-3,4-dihydro-4,6,8-trihydroxy-1(2H)-naphthalenone (5), (-)-scytalone (6), (3S, 4S)-3,4-dihydro-3,4,6,8-tetrahydroxy-1(2H)-naphthalenone (7), and cis-4-hydroxyscytalone (8). Compounds 4-8 were isolated from the Pleosporales fungi for the first time. Compound 1 shows inhibitory activities against human cervical carcinoma cell line HeLa and murine leukemia cell line P388 with the IC50 values of 78.93 and 98.80 μmol·L-1, respectively.

Pleosporales fungus  /  secondary metabolite  /  naphthoquinone  /  naphthalenone  /  tricarboxylic acid  /  cytotoxic activity
Si-yuan QI, Li-hua ZHANG, Yi-nan HAO, You-cai HU, Jian BAI. Naphthoquinone and carboxylic acid derivatives from the fungus Pleosporales sp.[J]. Acta Pharmaceutica Sinica, 2024 , 59 (5) : 1327 -1333 . DOI: 10.16438/j.0513-4870.2023-1269
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Article Info
doi: 10.16438/j.0513-4870.2023-1269
  • Receive Date：2023-11-10
  • Online Date：2025-11-27
  • Published：2024-05-12
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  • Received：2023-11-10
  • Revised：2023-12-15
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    Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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