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Study of phenylpropanoids from Tripterygium hypoglaucum
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Zhi-qi LIN, Hong-bo ZHU, Tang ZHOU, Ji WANG, Rong-ping ZHANG, Xing-long CHEN*
Acta Pharmaceutica Sinica | 2024, 59(6) : 1730 - 1740
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Acta Pharmaceutica Sinica | 2024, 59(6): 1730-1740
• Original Articles •
Study of phenylpropanoids from Tripterygium hypoglaucum
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Zhi-qi LIN, Hong-bo ZHU, Tang ZHOU, Ji WANG, Rong-ping ZHANG, Xing-long CHEN*
Affiliations
  • School of Chinese Materia Medica & Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China
Published: 2024-06-12 doi: 10.16438/j.0513-4870.2023-1268
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This paper aimed to study phenylpropanoids of Tripterygium hypoglaucum. Twenty-four compounds were isolated from the 70% EtOH extracts of T. hypoglaucum by silica gel column chromatography, reversed phase column chromatography, gel column chromatography, preparative thin layer chromatography, and semi-preparative high performance liquid chromatography. Compounds 1-3 were three new phenylpropionds. Their structures were identified by ultraviolet spectrum, infrared spectroscopy, high resolution electrospray ionization mass spectrometry, and nuclear magnetic resonance data as: threo-2-(4-hydroxy-3-methoxyphenoxy)-3-(4-hydroxy-3-methoxyphenyl)-1, 3-propanedol (1), erythro-2-(4-hydroxy-3-methoxyphenoxy)-3-(4-hydroxy-3-methoxyphenyl)-1, 3-propanediol (2), erythro-3-(4-hydroxy-3, 5-dimethoxyphenyl)-3-ethoxypropane-1, 2-propanediol (3). Compounds 4-6, 9, 14, 15, 18, 19, and 21-24 were obtained from Tripterygium genus for the first time. The cytotoxicity assay of cancer cells suggested that compound 20 displayed cytotoxicity on the breast cancer 4T1 cells whose 50% inhibitory concentration was 125.60 μmol·L-1.

Tripterygium hypoglaucum  /  chemical constituent  /  phenylpropanoid  /  lignan  /  cytotoxicity
Zhi-qi LIN, Hong-bo ZHU, Tang ZHOU, Ji WANG, Rong-ping ZHANG, Xing-long CHEN. Study of phenylpropanoids from Tripterygium hypoglaucum[J]. Acta Pharmaceutica Sinica, 2024 , 59 (6) : 1730 -1740 . DOI: 10.16438/j.0513-4870.2023-1268
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doi: 10.16438/j.0513-4870.2023-1268
  • Receive Date：2023-11-09
  • Online Date：2025-11-26
  • Published：2024-06-12
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  • Received：2023-11-09
  • Revised：2024-01-12
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    School of Chinese Materia Medica & Yunnan Key Laboratory of Southern Medicine Utilization, Yunnan University of Chinese Medicine, Kunming 650500, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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