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Research progress on the application of membrane biomimetic nanocarriers in targeted therapy of lung diseases
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Wen-jing BAI1, Rong GUO2, Lin XIONG1, Leng-jing ZHU1, Jia-xin LI1, Ya-shi WANG1, Man LI1, Qin HE1, *
Acta Pharmaceutica Sinica | 2024, 59(10) : 2730 - 2740
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Acta Pharmaceutica Sinica | 2024, 59(10): 2730-2740
Research progress on the application of membrane biomimetic nanocarriers in targeted therapy of lung diseases
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Wen-jing BAI1, Rong GUO2, Lin XIONG1, Leng-jing ZHU1, Jia-xin LI1, Ya-shi WANG1, Man LI1, Qin HE1, *
Affiliations
  • 1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
  • 2. West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China
Published: 2024-10-12 doi: 10.16438/j.0513-4870.2023-1205
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Pulmonary disease is one of the major threats to human health. However, the current clinical treatment drugs for lung diseases generally have problems such as low lung delivery efficiency, fast clearance rate and obvious toxic side effects. Recently, membrane biomimetic nanocarriers have attracted more and more attention. Due to their advantages of high targeting, long cycle time, good biocompatibility and strong immune escape ability, membrane biomimetic nanocarriers have become a major research hotspot in targeted therapy of lung diseases. In this review, we discuss the main preparation methods of membrane biomimetic nanoparticles, the characteristics of membrane biomimetic nanocarriers from different cell sources and their application in the targeted therapy of lung diseases. At the same time, according to the characteristics of different membranes, the shortcomings, current technical limitations and future prospects are discussed. This review is expected to provide references for the design of membrane biomimetic nanocarriers and their potential applications in the treatment of lung diseases.

pulmonary disease  /  lung targeted  /  membrane  /  biomimetic nanoparticle  /  drug delivery system
Wen-jing BAI, Rong GUO, Lin XIONG, Leng-jing ZHU, Jia-xin LI, Ya-shi WANG, Man LI, Qin HE. Research progress on the application of membrane biomimetic nanocarriers in targeted therapy of lung diseases[J]. Acta Pharmaceutica Sinica, 2024 , 59 (10) : 2730 -2740 . DOI: 10.16438/j.0513-4870.2023-1205
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Article Info
doi: 10.16438/j.0513-4870.2023-1205
  • Receive Date：2024-02-23
  • Online Date：2025-11-24
  • Published：2024-10-12
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History
  • Received：2024-02-23
  • Revised：2024-06-11
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Affiliations
    1. Key Laboratory of Drug Targeting and Drug Delivery Systems, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu 610041, China
    2. West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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