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Clinical research progress on drugs for non-alcoholic steatohepatitis treatment
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Cai-hong LIU1, 2, Shao-cong HOU1, 2, Ping-ping LI1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(12) : 3528 - 3538
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Acta Pharmaceutica Sinica | 2023, 58(12): 3528-3538
Clinical research progress on drugs for non-alcoholic steatohepatitis treatment
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Cai-hong LIU1, 2, Shao-cong HOU1, 2, Ping-ping LI1, 2, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. CAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis, Beijing 100050, China
Published: 2023-12-12 doi: 10.16438/j.0513-4870.2023-1199
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Nonalcoholic steatohepatitis (NASH) is the leading chronic liver disease worldwide. NASH is commonly associated with metabolic risk factors, including obesity, hypertension, and diabetes. Hepatic glucose and lipid metabolism disorder, bile acid toxicity, oxidative stress, inflammation, fibrosis, intestinal dysbacteriosis, and susceptibility gene variation are involved in the pathogenesis of NASH. Drug development for NASH has been slow, this article focuses on the clinical research and development of several promising NASH drugs and their mechanisms, such as drugs targeting gut-liver axis, improving metabolism, inhibiting inflammation and fibrosis.

nonalcoholic steatohepatitis  /  lipid metabolism  /  gut-liver axis  /  anti-inflammation  /  anti-fibrosis
Cai-hong LIU, Shao-cong HOU, Ping-ping LI. Clinical research progress on drugs for non-alcoholic steatohepatitis treatment[J]. Acta Pharmaceutica Sinica, 2023 , 58 (12) : 3528 -3538 . DOI: 10.16438/j.0513-4870.2023-1199
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Article Info
doi: 10.16438/j.0513-4870.2023-1199
  • Receive Date：2023-10-24
  • Online Date：2025-11-21
  • Published：2023-12-12
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History
  • Received：2023-10-24
  • Revised：2023-11-13
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Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. CAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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