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Research progress in regulation and mechanism of transcription factors on tanshinones
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Yan-hong BAI1, Lin-lin XIN1, Ting ZENG1, 2, Feng-xia HAN1, Yong-qing ZHANG1, Gao-bin PU1, Xue CHEN1, *, Qian LIU1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(5) : 1218 - 1228
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Acta Pharmaceutica Sinica | 2024, 59(5): 1218-1228
• Reviews •
Research progress in regulation and mechanism of transcription factors on tanshinones
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Yan-hong BAI1, Lin-lin XIN1, Ting ZENG1, 2, Feng-xia HAN1, Yong-qing ZHANG1, Gao-bin PU1, Xue CHEN1, *, Qian LIU1, 2, *
Affiliations
  • 1. College of Pharmacy, Shandong University of Chinese Medicine, Jinan 250355, China
  • 2. LiShizhen College of Traditional Chinese Medicine, Huanggang Normal University, Huanggang 438000, China
Published: 2024-05-12 doi: 10.16438/j.0513-4870.2023-1110
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Salvia miltiorrhiza, a commonly used traditional Chinese medicine, has been widely recognized for its blood-activating and stasis-removing properties in the clinical treatment of cardiovascular and cerebrovascular diseases. The synthesis and regulatory mechanism of tanshinones, the key active constituents of Salvia miltiorrhiza, have been a hot topic of research. The paper summarized the research findings on the regulation of tanshinone biosynthesis by transcription factors such as AP2/ERF, bHLH, MYB, bZIP, and WRKY in recent years. The review identifies the existing issues in the transcriptional regulation studies of Salvia miltiorrhiza and discusses the research direction of transcription factors in the regulation of tanshinone biosynthesis, providing a theoretical basis for the further discovery and utilization of functional genes involved in the regulation of tanshinone bioactive constituents.

transcription factor  /  tanshinone  /  regulation  /  molecular mechanism
Yan-hong BAI, Lin-lin XIN, Ting ZENG, Feng-xia HAN, Yong-qing ZHANG, Gao-bin PU, Xue CHEN, Qian LIU. Research progress in regulation and mechanism of transcription factors on tanshinones[J]. Acta Pharmaceutica Sinica, 2024 , 59 (5) : 1218 -1228 . DOI: 10.16438/j.0513-4870.2023-1110
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Article Info
doi: 10.16438/j.0513-4870.2023-1110
  • Receive Date：2023-09-26
  • Online Date：2025-11-27
  • Published：2024-05-12
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History
  • Received：2023-09-26
  • Revised：2023-12-14
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Affiliations
    1. College of Pharmacy, Shandong University of Chinese Medicine, Jinan 250355, China
    2. LiShizhen College of Traditional Chinese Medicine, Huanggang Normal University, Huanggang 438000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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