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Research progress of the protection provided by traditional Chinese medicine on non-alcoholic fatty liver disease via regulating liver macrophages
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Ke-ke WANG1, Wang-ya JIA1, Zhen-lin HUANG1, Jian LI2, 3, Hong XU1, *, Li-li JI1, *
Acta Pharmaceutica Sinica | 2024, 59(4) : 801 - 810
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Acta Pharmaceutica Sinica | 2024, 59(4): 801-810
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Research progress of the protection provided by traditional Chinese medicine on non-alcoholic fatty liver disease via regulating liver macrophages
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Ke-ke WANG1, Wang-ya JIA1, Zhen-lin HUANG1, Jian LI2, 3, Hong XU1, *, Li-li JI1, *
Affiliations
  • 1. The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
  • 2. China Pharmaceutical University, Nanjing 210009, China
  • 3. Technology Center of Jinling Pharmaceutical Co., Ltd., Nanjing 210009, China
Published: 2024-04-12 doi: 10.16438/j.0513-4870.2023-1100
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Non-alcoholic fatty liver disease (NAFLD) is a pathological syndrome characterized by the excessive deposition of lipids in hepatocytes but not caused by alcohol and other definite liver damage factors. The pathogenesis of NAFLD is complex. When the liver is damaged, a large amount of lipids deposited in hepatocytes will induce oxidative stress injury, endoplasmic reticulum stress and metabolic disorders in hepatocytes, and immune cells further secrete inflammatory cytokines and release them into the blood, causing systemic inflammation. In the process of NAFLD, the inflammatory response plays an important role. Macrophages are the most abundant non-parenchymal cells in the liver and play an important role in liver inflammatory injury. Hepatic macrophages include liver-native and monocyte-derived macrophages, and their activation and polarization processes are involved in the different development stages of NAFLD. Traditional Chinese medicine (TCM) compound and its active compounds have been found to regulate macrophages to participate in the process of inflammation, injury and recovery of NAFLD. Based on the existing research reports, this paper elaborates the relationship between the source, activation and polarization of macrophages and NAFLD as the breakthrough point, and systematically reviews the mechanism of TCM in the prevention and treatment of NAFLD by regulating the activation, recruitment and polarization of macrophages. This paper aims to provide new ideas for the discovery of novel NAFLD candidate drugs from TCM via targeting macrophages.

non-alcoholic fatty liver disease  /  traditional Chinese medicine  /  traditional Chinese medicine compound  /  active compound  /  macrophage
Ke-ke WANG, Wang-ya JIA, Zhen-lin HUANG, Jian LI, Hong XU, Li-li JI. Research progress of the protection provided by traditional Chinese medicine on non-alcoholic fatty liver disease via regulating liver macrophages[J]. Acta Pharmaceutica Sinica, 2024 , 59 (4) : 801 -810 . DOI: 10.16438/j.0513-4870.2023-1100
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Article Info
doi: 10.16438/j.0513-4870.2023-1100
  • Receive Date：2023-09-24
  • Online Date：2025-11-28
  • Published：2024-04-12
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History
  • Received：2023-09-24
  • Revised：2023-11-17
Funding
Affiliations
    1. The MOE Key Laboratory for Standardization of Chinese Medicines, Shanghai Key Laboratory of Compound Chinese Medicines, The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China
    2. China Pharmaceutical University, Nanjing 210009, China
    3. Technology Center of Jinling Pharmaceutical Co., Ltd., Nanjing 210009, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
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Percentage of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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