Home Journals Articles Updates About
CN
image
收藏切换
Chemical diversity of azaphilones from the marine-derived fungus Talaromyces sp. HK1-18
收藏切换
PDF
Jia-cheng XUE1, Zhong-hui LI1, 3, Bao-cong HAO1, Yao-yao ZHENG3, Xia-hao ZHU1, Zhi-xin CHEN1, Min CHEN1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(5) : 1478 - 1483
Less
收藏切换
Acta Pharmaceutica Sinica | 2024, 59(5): 1478-1483
• Original Articles •
Chemical diversity of azaphilones from the marine-derived fungus Talaromyces sp. HK1-18
Full
Jia-cheng XUE1, Zhong-hui LI1, 3, Bao-cong HAO1, Yao-yao ZHENG3, Xia-hao ZHU1, Zhi-xin CHEN1, Min CHEN1, 2, *
Affiliations
  • 1. Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, Yangzhou 225127, China
  • 2. Jiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang 222005, China
  • 3. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
Published: 2024-05-12 doi: 10.16438/j.0513-4870.2023-1091
Outline
收藏切换

GNPS-based mass spectrum-molecular networks is an effective strategy for rapidly identifying known natural products and discovering novel structures. The chemical diversity of azaphilones from the fermentation extracts of Talaromyces sp. HK1-18 was studied by molecular network technique. Three linear tricyclic azaphilones, sequoiamonacins A-C (2a, 2b, 1), were isolated by silica gel column chromatography and high performance liquid chromatography from the extracts of the fungal strain of HK1-18, and their structures were identified by nuclear magnetic resonance and high-resolution mass spectrometry. Guided by the mass spectra of sequoiamonacins A-C (2a, 2b, 1), the cluster of sequoiamonacinoid analogues was discovered from the full molecular networking of HK1-18. By analyzing the MS/MS fragments of each parent ion in this cluster, 7 azaphilones (3-9) included 6 new ones (4-9) were predicted successfully. Then the MS/MS cracking regularity of this type of azaphilones was revealed. Compound 1 showed anti-inflammatory activity, which can inhibit the production of interleukin-1α (IL-1α) in lipopolysaccharide (LPS)-induced mouse macrophage RAW264.7, with an inhibitory rate of 29% at the concentration of 12.5 μg·mL-1.

marine-derived fungus  /  azaphilone  /  molecular network  /  structure prediction  /  sequoiamonacin
Jia-cheng XUE, Zhong-hui LI, Bao-cong HAO, Yao-yao ZHENG, Xia-hao ZHU, Zhi-xin CHEN, Min CHEN. Chemical diversity of azaphilones from the marine-derived fungus Talaromyces sp. HK1-18[J]. Acta Pharmaceutica Sinica, 2024 , 59 (5) : 1478 -1483 . DOI: 10.16438/j.0513-4870.2023-1091
Appendix
Less
Year 2024 volume 59 Issue 5
PDF
182
92
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2023-1091
  • Receive Date：2023-09-21
  • Online Date：2025-11-27
  • Published：2024-05-12
Article Data
Affiliations
History
  • Received：2023-09-21
  • Revised：2024-01-02
Funding
Affiliations
    1. Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, Yangzhou 225127, China
    2. Jiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang 222005, China
    3. Key Laboratory of Marine Drugs, Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2023-1091
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House