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Key issues in the study of drug nanocrystals self-stabilized Pickering emulsions as drug delivery system
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Ji-fen ZHANG1, Fang-ming DONG1, Chuan LIU2, Tao YI3, *
Acta Pharmaceutica Sinica | 2024, 59(6) : 1582 - 1592
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Acta Pharmaceutica Sinica | 2024, 59(6): 1582-1592
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Key issues in the study of drug nanocrystals self-stabilized Pickering emulsions as drug delivery system
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Ji-fen ZHANG1, Fang-ming DONG1, Chuan LIU2, Tao YI3, *
Affiliations
  • 1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China
  • 2. Chengdu Institute of Food Inspection, Chengdu 611130, China
  • 3. Faculty of Health Sciences and Sports, Macao Polytechnic University, Macao 999078, China
Published: 2024-06-12 doi: 10.16438/j.0513-4870.2023-1022
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Drug nanocrystals self-stabilized Pickering emulsion (DNSPE) is a novel Pickering emulsion with drug nanocrystals as the stabilizer. There are more and more researches on DNSPE in the field of drug delivery in recent years. On the basis of summarizing the research status of DNSPE used as drug delivery systems, this paper comprehensively reviewed the research progress of three key issues, such as the main factors affecting construction of DNSPE, characterization methods of properties and structures, and in vivo fate, and looked forward to the industrialization prospect, which is beneficial to deepen the comprehensive research of DNSPE and promote its application in the field of drug delivery.

Pickering emulsion  /  drug delivery  /  nanocrystal  /  structure characteristic  /  fate in vivo
Ji-fen ZHANG, Fang-ming DONG, Chuan LIU, Tao YI. Key issues in the study of drug nanocrystals self-stabilized Pickering emulsions as drug delivery system[J]. Acta Pharmaceutica Sinica, 2024 , 59 (6) : 1582 -1592 . DOI: 10.16438/j.0513-4870.2023-1022
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Article Info
doi: 10.16438/j.0513-4870.2023-1022
  • Receive Date：2023-09-01
  • Online Date：2025-11-26
  • Published：2024-06-12
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History
  • Received：2023-09-01
  • Revised：2024-04-18
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Affiliations
    1. College of Pharmaceutical Sciences, Southwest University, Chongqing 400716, China
    2. Chengdu Institute of Food Inspection, Chengdu 611130, China
    3. Faculty of Health Sciences and Sports, Macao Polytechnic University, Macao 999078, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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