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Research progress in micro/nanobubbles for ultrasound diagnosis or treatment
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Qing-qing AN1, Chen-xi LI1, Shao-kun YANG1, Xiao-ming HE1, Yue-heng WANG2, Chao-xing HE1, *, Bai XIANG1, *
Acta Pharmaceutica Sinica | 2024, 59(3) : 581 - 590
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Acta Pharmaceutica Sinica | 2024, 59(3): 581-590
• Reviews •
Research progress in micro/nanobubbles for ultrasound diagnosis or treatment
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Qing-qing AN1, Chen-xi LI1, Shao-kun YANG1, Xiao-ming HE1, Yue-heng WANG2, Chao-xing HE1, *, Bai XIANG1, *
Affiliations
  • 1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
  • 2. The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
Published: 2024-03-12 doi: 10.16438/j.0513-4870.2023-0873
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In the past few decades, microbubbles were widely used as ultrasound contrast agents in the field of tumor imaging. With the development of research, ultrasound targeted microbubble destruction technology combined with drug-loaded microbubbles can achieve precise drug release and play a therapeutic role. As a micron-scale carrier, microbubbles are difficult to penetrate the endothelial cell space of tumors, and nano-scale drug delivery system—nanobubbles came into being. The structure of the two is similar, but the difference in size highlights the unique advantages of nanobubbles in drug delivery. Based on the classification principle of shell materials, this review summarized micro/nanobubbles used for ultrasound diagnosis or treatment and discussed the possible development directions, providing references for the subsequent development.

ultrasound contrast agent  /  microbubble  /  nanobubble  /  ultrasound targeted microbubble destruction  /  diagnosis  /  therapy
Qing-qing AN, Chen-xi LI, Shao-kun YANG, Xiao-ming HE, Yue-heng WANG, Chao-xing HE, Bai XIANG. Research progress in micro/nanobubbles for ultrasound diagnosis or treatment[J]. Acta Pharmaceutica Sinica, 2024 , 59 (3) : 581 -590 . DOI: 10.16438/j.0513-4870.2023-0873
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Year 2024 volume 59 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2023-0873
  • Receive Date：2023-07-14
  • Online Date：2025-11-28
  • Published：2024-03-12
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History
  • Received：2023-07-14
  • Revised：2024-01-22
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Affiliations
    1. School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
    2. The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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