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Effect of type of carrier material on the in vitro properties of solid dispersions of progesterone
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Jing-nan QUAN1, 2, Yi CHENG2, Jing-yu ZHOU2, Meng LI2, Zeng-ming WANG2, Nan LIU2, Zi-ming ZHAO1, *, Hui ZHANG2, *, Ai-ping ZHENG1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(3) : 735 - 742
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Acta Pharmaceutica Sinica | 2024, 59(3): 735-742
• Original Articles •
Effect of type of carrier material on the in vitro properties of solid dispersions of progesterone
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Jing-nan QUAN1, 2, Yi CHENG2, Jing-yu ZHOU2, Meng LI2, Zeng-ming WANG2, Nan LIU2, Zi-ming ZHAO1, *, Hui ZHANG2, *, Ai-ping ZHENG1, 2, *
Affiliations
  • 1. School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
  • 2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
Published: 2024-03-12 doi: 10.16438/j.0513-4870.2023-0831
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This study investigated the effect of different carrier materials on the in vitro properties of progesterone solid dispersions. The solid dispersions of the insoluble drug progesterone were prepared by hot melt extrusion technique using rheological properties as the index of investigation, and the in vitro properties of the solid dispersions were characterized. Scanning electron microscope revealed solid dispersions with rough surfaces and agglomerated microstructures into irregular lumpy particles. Differential scanning calorimetry and powder X-ray diffraction showed the change of progesterone crystalline form in solid dispersions from crystalline to amorphous state. In vitro dissolution studies showed that solid dispersions prepared with different carrier materials can effectively improve the dissolution rate of drugs. The results of the study showed that the type of carrier material had a significant effect on the in vitro properties of solid dispersions, providing a reference for the study of solid dispersions in the controlled release of insoluble drugs.

progesterone  /  hot melt extrusion  /  carrier material  /  solid dispersion  /  dissolution
Jing-nan QUAN, Yi CHENG, Jing-yu ZHOU, Meng LI, Zeng-ming WANG, Nan LIU, Zi-ming ZHAO, Hui ZHANG, Ai-ping ZHENG. Effect of type of carrier material on the in vitro properties of solid dispersions of progesterone[J]. Acta Pharmaceutica Sinica, 2024 , 59 (3) : 735 -742 . DOI: 10.16438/j.0513-4870.2023-0831
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Article Info
doi: 10.16438/j.0513-4870.2023-0831
  • Receive Date：2023-07-05
  • Online Date：2025-11-28
  • Published：2024-03-12
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History
  • Received：2023-07-05
  • Revised：2023-12-25
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Affiliations
    1. School of Pharmacy, Xuzhou Medical University, Xuzhou 221004, China
    2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Academy of Military Sciences, Beijing 100850, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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