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A new suberin from roots of Ephedra sinica Stapf
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Bo-wen ZHANG1, 2, Meng LI1, 2, Xiao-lan WANG1, 2, Ying YANG1, 2, Shi-qi ZHOU1, 2, Si-qi TAO1, 2, Meng YANG1, 2, Deng-hui ZHU1, 2, Ya-tong XU1, 2, Wei-sheng FENG1, 2, Xiao-ke ZHENG1, 2, *
Acta Pharmaceutica Sinica | 2024, 59(3) : 661 - 666
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Acta Pharmaceutica Sinica | 2024, 59(3): 661-666
• Original Articles •
A new suberin from roots of Ephedra sinica Stapf
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Bo-wen ZHANG1, 2, Meng LI1, 2, Xiao-lan WANG1, 2, Ying YANG1, 2, Shi-qi ZHOU1, 2, Si-qi TAO1, 2, Meng YANG1, 2, Deng-hui ZHU1, 2, Ya-tong XU1, 2, Wei-sheng FENG1, 2, Xiao-ke ZHENG1, 2, *
Affiliations
  • 1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
  • 2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
Published: 2024-03-12 doi: 10.16438/j.0513-4870.2023-0729
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Six compounds were isolated from the roots of Ephedra sinica Stapf using various chromatographic techniques such as silica gel column chromatography, thin layer chromatography and semi-preparative HPLC. Their chemical structures were identified by analysis of physicochemical properties and spectral data, and determined as (Z)-docosanylferulate (1), (E)-docosanylferulate (2), bis (2-ethylheptyl) phythalate (3), 2, 2′-oxybis (1, 4-di-tert-butylbenzene) (4), diisobutyl phthalate (5), bis (2-ethylhexyl) phthalate (6). Among them, compound 1 is a new compound, compounds 2-4 were first isolated from Ephedra. A corticosterone-induced PC-12 cell injury model was used for compound activity screening. The results showed that compounds 1 and 5 significantly improved corticosterone-induced PC-12 cell injury and significantly increased 5-HT7 receptor protein expression in the cells, indicating potential antidepressant activity.

root of Ephedra sinica Stapf  /  chemical constituent  /  suberin  /  (Z)-docosanylferulate  /  antidepressant activity
Bo-wen ZHANG, Meng LI, Xiao-lan WANG, Ying YANG, Shi-qi ZHOU, Si-qi TAO, Meng YANG, Deng-hui ZHU, Ya-tong XU, Wei-sheng FENG, Xiao-ke ZHENG. A new suberin from roots of Ephedra sinica Stapf[J]. Acta Pharmaceutica Sinica, 2024 , 59 (3) : 661 -666 . DOI: 10.16438/j.0513-4870.2023-0729
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Year 2024 volume 59 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2023-0729
  • Receive Date：2023-06-08
  • Online Date：2025-11-28
  • Published：2024-03-12
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  • Received：2023-06-08
  • Revised：2023-08-21
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Affiliations
    1. School of Pharmacy, Henan University of Chinese Medicine, Zhengzhou 450046, China
    2. The Engineering and Technology Center for Chinese Medicine Development of Henan Province, Zhengzhou 450046, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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