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Research progress on endogenous small-molecule phenolics and the proposal of "phenolomics"
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Hong-qian KUI1, Chuan-xin LIU2, Qiang WANG1, Hai-feng ZHAI3, *, Jian-mei HUANG1, *
Acta Pharmaceutica Sinica | 2024, 59(2) : 336 - 349
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Acta Pharmaceutica Sinica | 2024, 59(2): 336-349
• Reviews •
Research progress on endogenous small-molecule phenolics and the proposal of "phenolomics"
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Hong-qian KUI1, Chuan-xin LIU2, Qiang WANG1, Hai-feng ZHAI3, *, Jian-mei HUANG1, *
Affiliations
  • 1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
  • 2. School of Clinical Medicine, Henan University of Science and Technology, Endocrinology and Metabolism Center, The First Affiliated Hospital of Henan University of Science and Technology, Henan Key Laboratory of Rare Diseases, Luoyang 471003, China
  • 3. National Institute on Drug Dependence, Peking University, Beijing 100191, China
Published: 2024-02-12 doi: 10.16438/j.0513-4870.2023-0728
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Small-molecule phenolic substances widely exist in animals and plants, and have some shared biological activities. The metabolism of phenylalanine and tyrosine in the human body, and especially the metabolism of catecholamine neurotransmitters, produces endogenous small-molecule phenols. Endogenous small-molecule phenolic substances are functionally related to the important physiological processes and the occurrence of mental diseases in humans and some animals, which are systematically sorts and summarized in this review. Integrating the previous experimental research and literature analysis on natural small-molecule phenols by our research group, the understanding of the hypothesis that "small-molecule phenol are pharmacological signal carriers" was deepened. Based on above, the concept of "phenolomics" was further proposed, analyzed the research direction and research content which can bring into the knowledge framework of phenolomics. The induction of phenolomics will provide wider perspectives on explaining the pharmacological mechanism of drugs, discovering new drug targets, and finding biomarkers of mental diseases.

phenolomics  /  endogenous small-molecule phenol  /  natural small-molecule phenol  /  psychiatric disease  /  catecholamine neurotransmitter
Hong-qian KUI, Chuan-xin LIU, Qiang WANG, Hai-feng ZHAI, Jian-mei HUANG. Research progress on endogenous small-molecule phenolics and the proposal of "phenolomics"[J]. Acta Pharmaceutica Sinica, 2024 , 59 (2) : 336 -349 . DOI: 10.16438/j.0513-4870.2023-0728
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doi: 10.16438/j.0513-4870.2023-0728
  • Receive Date：2023-06-08
  • Online Date：2025-11-28
  • Published：2024-02-12
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History
  • Received：2023-06-08
  • Revised：2023-09-01
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Affiliations
    1. School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China
    2. School of Clinical Medicine, Henan University of Science and Technology, Endocrinology and Metabolism Center, The First Affiliated Hospital of Henan University of Science and Technology, Henan Key Laboratory of Rare Diseases, Luoyang 471003, China
    3. National Institute on Drug Dependence, Peking University, Beijing 100191, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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