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Research progress of IDO1-mediated tryptophan metabolism in sepsis
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Xiao-di ZHAO1, Cheng-yan MA2, Hua-qing CUI1, Yu-chen WANG1, Xiao-guang CHEN1, Sen ZHANG1, *
Acta Pharmaceutica Sinica | 2024, 59(2) : 289 - 297
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Acta Pharmaceutica Sinica | 2024, 59(2): 289-297
• Reviews •
Research progress of IDO1-mediated tryptophan metabolism in sepsis
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Xiao-di ZHAO1, Cheng-yan MA2, Hua-qing CUI1, Yu-chen WANG1, Xiao-guang CHEN1, Sen ZHANG1, *
Affiliations
  • 1. State Key Laboratory of Active Substances and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
Published: 2024-02-12 doi: 10.16438/j.0513-4870.2023-0725
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Sepsis is a condition characterized by organ dysfunction resulting from the systemic inflammatory response triggered by an infection. Excessive inflammation and immunosuppression are intertwined, and severe cases may even develop into multiple organ failure. Studies have shown that indoleamine 2, 3-dioxygenase 1-mediated tryptophan metabolism is involved in the occurrence and development of sepsis, and elevated plasma kynurenine levels and Kyn/Trp ratios are early indicators of sepsis development. In this paper, we provide a comprehensive summary of the role of IDO1 in the acute inflammatory phase of sepsis, late immunosuppression, and organ damage. This includes its regulation of inflammatory state, immune cell function, blood pressure, and other aspects. Additionally, we analyze preclinical studies on targeted IDO1 drugs. An in-depth understanding and study of IDO may help to understand the pathogenesis and clinical significance of sepsis and multiple organ damage from a new perspective and provide new research ideas for exploring its prevention and treatment methods.

sepsis  /  indoleamine 2  /  3-dioxygenase 1  /  immune activation  /  inflammation  /  hypotension
Xiao-di ZHAO, Cheng-yan MA, Hua-qing CUI, Yu-chen WANG, Xiao-guang CHEN, Sen ZHANG. Research progress of IDO1-mediated tryptophan metabolism in sepsis[J]. Acta Pharmaceutica Sinica, 2024 , 59 (2) : 289 -297 . DOI: 10.16438/j.0513-4870.2023-0725
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Article Info
doi: 10.16438/j.0513-4870.2023-0725
  • Receive Date：2023-06-07
  • Online Date：2025-11-28
  • Published：2024-02-12
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History
  • Received：2023-06-07
  • Revised：2023-08-31
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Affiliations
    1. State Key Laboratory of Active Substances and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Institute of Laboratory Animals Science, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
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多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
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小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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