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Advances in Salmonella-mediated targeted tumor therapy
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Zhao-rui LÜ1, Dong-yi LI1, Yu-yang ZHU1, He-qi HUANG1, Hao-nan LI1, Zi-chun HUA1, 2, 3, *
Acta Pharmaceutica Sinica | 2024, 59(1) : 17 - 24
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Acta Pharmaceutica Sinica | 2024, 59(1): 17-24
• Reviews •
Advances in Salmonella-mediated targeted tumor therapy
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Zhao-rui LÜ1, Dong-yi LI1, Yu-yang ZHU1, He-qi HUANG1, Hao-nan LI1, Zi-chun HUA1, 2, 3, *
Affiliations
  • 1. School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China
  • 2. School of Life Sciences, Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing 210023, China
  • 3. Nanjing Genrecom Laboratories, Ltd., Nanjing 210032, China
Published: 2024-01-12 doi: 10.16438/j.0513-4870.2023-0700
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Salmonella has emerged as a promising tumor-targeting strategy in recent years due to its good tumor targeting ability and certain safety. In order to further optimize its therapeutic effect, scientists have tried to modify Salmonella, including its attenuation and drug loading. This paper summarizes the mechanism and research progress of Salmonella-mediated targeted tumor therapy, and introduces the strategies and related progress of its modification and optimization. At the same time, the advantages, current challenges and future development directions of Salmonella-mediated tumor therapy are summarized.

Salmonella  /  tumor  /  targeted therapy  /  attenuation  /  oncolytic bacteria
Zhao-rui LÜ, Dong-yi LI, Yu-yang ZHU, He-qi HUANG, Hao-nan LI, Zi-chun HUA. Advances in Salmonella-mediated targeted tumor therapy[J]. Acta Pharmaceutica Sinica, 2024 , 59 (1) : 17 -24 . DOI: 10.16438/j.0513-4870.2023-0700
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Article Info
doi: 10.16438/j.0513-4870.2023-0700
  • Receive Date：2023-06-01
  • Online Date：2025-11-28
  • Published：2024-01-12
Article Data
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History
  • Received：2023-06-01
  • Revised：2023-08-28
Funding
Affiliations
    1. School of Biopharmacy, China Pharmaceutical University, Nanjing 211198, China
    2. School of Life Sciences, Nanjing University, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing 210023, China
    3. Nanjing Genrecom Laboratories, Ltd., Nanjing 210032, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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