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Subcellular localization of macrophage migration inhibitory factor and its diverse biological functions in tumors
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Huan ZHANG, Chen YANG, Shuang SHANG, Xiao-xi LV, Fang HUA*
Acta Pharmaceutica Sinica | 2023, 58(8) : 2085 - 2097
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Acta Pharmaceutica Sinica | 2023, 58(8): 2085-2097
Subcellular localization of macrophage migration inhibitory factor and its diverse biological functions in tumors
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Huan ZHANG, Chen YANG, Shuang SHANG, Xiao-xi LV, Fang HUA*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (BZ0150), CAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis, Institute of Meteria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-08-12 doi: 10.16438/j.0513-4870.2023-0623
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Macrophage migration inhibitory factor (MIF) is an enzyme-active pleiotropic cytokine that is expressed in various immune cells and tumor cells. MIF plays diverse roles in inflammation and tumor progression. It acts as a cytokine involved in immune response and inflammatory lesions. Additionally, MIF is closely associated with tumor proliferation, metastasis, and other tumor hallmarks, exerting a multifaceted influence on tumor occurrence and progression. MIF not only functions by being secreted into the extracellular space as a cytokine but can also be localized within the cytoplasm and nucleus, exhibiting diverse biological functions. As MIF in promoting tumor progression becomes increasingly recognized, MIF-based therapeutic strategies have become a hot research topic in oncology. Here, we provide a comprehensive review of MIF with different subcellular localization about their pro-tumoral functions. A better understanding of MIF in tumor biology will bring broader perspectives for the development of novel MIF targeting strategies and give promising direction for future tumor treatments.

macrophage migration inhibitory factor  /  subcellular localization  /  tumor  /  tumor microenvironment  /  targeted therapy
Huan ZHANG, Chen YANG, Shuang SHANG, Xiao-xi LV, Fang HUA. Subcellular localization of macrophage migration inhibitory factor and its diverse biological functions in tumors[J]. Acta Pharmaceutica Sinica, 2023 , 58 (8) : 2085 -2097 . DOI: 10.16438/j.0513-4870.2023-0623
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doi: 10.16438/j.0513-4870.2023-0623
  • Receive Date：2023-05-13
  • Online Date：2025-11-21
  • Published：2023-08-12
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  • Received：2023-05-13
  • Revised：2023-06-07
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    State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Beijing Key Laboratory of New Drug Mechanisms and Pharmacological Evaluation Study (BZ0150), CAMS Key Laboratory of Molecular Mechanism and Target Discovery of Metabolic Disorder and Tumorigenesis, Institute of Meteria Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Family		 属数
Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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