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The role of lipid peroxidation in modulating immune function
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Xin-xing CHEN1, 2, 3, Shu-hua OUYANG1, 2, 3, Hiroshi KURIHARA1, 2, 3, Yi-fang LI1, 2, 3, Yan-ping WU1, 2, 3, *, Rong-rong HE1, 2, 3
Acta Pharmaceutica Sinica | 2023, 58(11) : 3230 - 3241
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Acta Pharmaceutica Sinica | 2023, 58(11): 3230-3241
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The role of lipid peroxidation in modulating immune function
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Xin-xing CHEN1, 2, 3, Shu-hua OUYANG1, 2, 3, Hiroshi KURIHARA1, 2, 3, Yi-fang LI1, 2, 3, Yan-ping WU1, 2, 3, *, Rong-rong HE1, 2, 3
Affiliations
  • 1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China
  • 2. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China
  • 3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
Published: 2023-11-12 doi: 10.16438/j.0513-4870.2023-0592
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The immune system plays a pivotal role in the pathogenesis and progression of diseases. Lipid peroxidation, as a key effector molecule in the execution of ferroptosis, exerts critical effects on the functionality and survival of various immune cells and is involved in the pathological processes of multiple diseases. There is accumulating evidence suggesting the presence of ferroptosis in immune cells as well. Lipid peroxidation is closely associated with immune cell function. Accumulation of lipid peroxidation products in immune cells can lead to ferroptosis, directly impacting immune cell function. Non-immune cells, through lipid peroxidation-mediated cell death, release signaling molecules that regulate immune cell function. They jointly influence the body's homeostasis. This article provides a comprehensive review of the latest research progress on the regulatory role of lipid peroxidation in immune function. It analyzes the relationship between lipid peroxidation and immune cells, and provides a theoretical foundation for potential strategies targeting cellular lipid peroxidation and immunotherapy in the treatment of diseases.

lipid peroxidation  /  immune cell  /  ferroptosis  /  immunotherapy
Xin-xing CHEN, Shu-hua OUYANG, Hiroshi KURIHARA, Yi-fang LI, Yan-ping WU, Rong-rong HE. The role of lipid peroxidation in modulating immune function[J]. Acta Pharmaceutica Sinica, 2023 , 58 (11) : 3230 -3241 . DOI: 10.16438/j.0513-4870.2023-0592
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doi: 10.16438/j.0513-4870.2023-0592
  • Receive Date：2023-05-08
  • Online Date：2025-11-21
  • Published：2023-11-12
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History
  • Received：2023-05-08
  • Revised：2023-06-09
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Affiliations
    1. Guangdong Engineering Research Center of Chinese Medicine and Disease Susceptibility, Jinan University, Guangzhou 510632, China
    2. Institute of Traditional Chinese Medicine and Natural Products, Jinan University, Guangzhou 510632, China
    3. Guangdong Province Key Laboratory of Pharmacodynamic Constituents of TCM and New Drugs Research, Jinan University, Guangzhou 510632, China
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表12种不同金属材料的力学参数
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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