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Recent advances in chemical fluorescent probes sensitive to tumor microenvironments
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Ke-liang LI1, Yang LIU2, Chun-yang LOU1, Tian-le HUANG1, Zhan-ying HONG1, Shan-chao WU1, *, Chun-quan SHENG1, *
Acta Pharmaceutica Sinica | 2023, 58(8) : 2180 - 2192
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Acta Pharmaceutica Sinica | 2023, 58(8): 2180-2192
Recent advances in chemical fluorescent probes sensitive to tumor microenvironments
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Ke-liang LI1, Yang LIU2, Chun-yang LOU1, Tian-le HUANG1, Zhan-ying HONG1, Shan-chao WU1, *, Chun-quan SHENG1, *
Affiliations
  • 1. The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China
  • 2. Department of Pharmacy, No. 971 Hospital of the People's Liberation Army Navy, Qingdao 266071, China
Published: 2023-08-12 doi: 10.16438/j.0513-4870.2023-0590
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Cancer seriously threatens human life and health, it is urgent for the development of rapid detection, precise localization and effective treatment of tumors. Chemical fluorescent probes that are sensitive to tumor-specific microenvironments have important significance in tumor theranostics and a variety of such probes have been developed. In this review, we classified chemical fluorescent probes that are sensitive to tumor microenvironments according to biological characteristics and microenvironmental changes while combining spectroscopy or response mechanisms, and systematically introduced the research progress of chemical fluorescent probes with sensitivity to hypoxia, low polarity, high viscosity, abnormal pH values and abundant reactive oxygen species in tumor microenvironments, in order to provide references for the development and applications of these probes.

tumor  /  tumor microenvironment  /  theranostics  /  chemical fluorescent probe
Ke-liang LI, Yang LIU, Chun-yang LOU, Tian-le HUANG, Zhan-ying HONG, Shan-chao WU, Chun-quan SHENG. Recent advances in chemical fluorescent probes sensitive to tumor microenvironments[J]. Acta Pharmaceutica Sinica, 2023 , 58 (8) : 2180 -2192 . DOI: 10.16438/j.0513-4870.2023-0590
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Article Info
doi: 10.16438/j.0513-4870.2023-0590
  • Receive Date：2023-05-08
  • Online Date：2025-11-21
  • Published：2023-08-12
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History
  • Received：2023-05-08
  • Revised：2023-07-12
Funding
Affiliations
    1. The Center for Basic Research and Innovation of Medicine and Pharmacy (MOE), School of Pharmacy, Second Military Medical University (Naval Medical University), Shanghai 200433, China
    2. Department of Pharmacy, No. 971 Hospital of the People's Liberation Army Navy, Qingdao 266071, China
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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