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Research progress of biomimetic nano drug delivery system in nervous system disease
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Chen-fei LIU, Cong-cong XIAO, Yan-hong LIU, Li-qing CHEN, Chao LIU, He-ming ZHAO, Ming-ji JIN, Zhong-gao GAO, Wei HUANG*
Acta Pharmaceutica Sinica | 2023, 58(8) : 2300 - 2310
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Acta Pharmaceutica Sinica | 2023, 58(8): 2300-2310
Research progress of biomimetic nano drug delivery system in nervous system disease
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Chen-fei LIU, Cong-cong XIAO, Yan-hong LIU, Li-qing CHEN, Chao LIU, He-ming ZHAO, Ming-ji JIN, Zhong-gao GAO, Wei HUANG*
Affiliations
  • Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-08-12 doi: 10.16438/j.0513-4870.2023-0549
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Brain delivery of drugs remains challenging due to the presence of the blood-brain barrier (BBB). With advances in nanotechnology and biotechnology, new possibilities for brain-targeted drug delivery have emerged. Biomimetic nano drug delivery systems with high brain-targeting and BBB-penetrating capabilities, along with good biocompatibility and safety, can enable 'invisible' drug delivery. In this review, five different types of biomimetic strategies are presented and their research progress in central nervous system disorders is reviewed. Finally, the challenges and future prospects for biomimetic nano drug delivery systems in intracerebral drug delivery are summarized.

biomimetic  /  nano drug delivery system  /  central nervous system disease  /  blood brain barrier
Chen-fei LIU, Cong-cong XIAO, Yan-hong LIU, Li-qing CHEN, Chao LIU, He-ming ZHAO, Ming-ji JIN, Zhong-gao GAO, Wei HUANG. Research progress of biomimetic nano drug delivery system in nervous system disease[J]. Acta Pharmaceutica Sinica, 2023 , 58 (8) : 2300 -2310 . DOI: 10.16438/j.0513-4870.2023-0549
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Article Info
doi: 10.16438/j.0513-4870.2023-0549
  • Receive Date：2023-05-03
  • Online Date：2025-11-21
  • Published：2023-08-12
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  • Received：2023-05-03
  • Revised：2023-06-05
Affiliations
    Beijing Key Laboratory of Drug Delivery Technology and Novel Formulations, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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