Home Journals Articles Updates About
CN
image
收藏切换
Research progress of small molecule fluorescent probes for ferrous ion and heme
收藏切换
PDF
Chen CHEN, Yi-xin CHEN, Chong-jing ZHANG*
Acta Pharmaceutica Sinica | 2023, 58(8) : 2250 - 2259
Less
收藏切换
Acta Pharmaceutica Sinica | 2023, 58(8): 2250-2259
Research progress of small molecule fluorescent probes for ferrous ion and heme
Full
Chen CHEN, Yi-xin CHEN, Chong-jing ZHANG*
Affiliations
  • State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
Published: 2023-08-12 doi: 10.16438/j.0513-4870.2023-0547
Outline
收藏切换

Small molecule fluorescent probes have gained widespread attention for their advantages of high selectivity, sensitivity, and easy to operate, and have played a critical role in the detection of various species. They have also demonstrated great potential in the field of biomedical research. Iron, as the most abundant transition metal in the human body, plays a vital role in many physiological functions. Due to the influence of the reductive microenvironment of cell, ferrous ion (Fe2+) is the main component of labile iron in living cells. Heme, consisting of Fe2+ and protoporphyrin IX, is one of the main signaling molecules that wrap biological iron in the human body, and also participates in many physiological and pathological processes. Therefore, the development of small molecule fluorescent probes for detecting Fe2+ and heme as effective monitoring tools will help to further understand their pathological and physiological functions, with potential applications in other fields. This review summarizes the research progress of small molecule fluorescent probes for Fe2+ and heme detection in recent years, and provides insights into future directions for their development.

small molecule fluorescent probe  /  ferrous ion  /  heme  /  reduction  /  cyclization  /  chelation
Chen CHEN, Yi-xin CHEN, Chong-jing ZHANG. Research progress of small molecule fluorescent probes for ferrous ion and heme[J]. Acta Pharmaceutica Sinica, 2023 , 58 (8) : 2250 -2259 . DOI: 10.16438/j.0513-4870.2023-0547
Appendix
Less
Year 2023 volume 58 Issue 8
PDF
180
76
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2023-0547
  • Receive Date：2023-05-03
  • Online Date：2025-11-21
  • Published：2023-08-12
Article Data
Affiliations
History
  • Received：2023-05-03
  • Revised：2023-05-25
Funding
Affiliations
    State Key Laboratory of Bioactive Substance and Function of Natural Medicines and Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2023-0547
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House