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Recent advances of antiviral drugs based on multispecific binding strategy
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Yang ZHOU, Shu-jing XU, Dang DING, Shuo WANG, Xin-yong LIU, Peng ZHAN*
Acta Pharmaceutica Sinica | 2023, 58(8) : 2203 - 2217
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Acta Pharmaceutica Sinica | 2023, 58(8): 2203-2217
Recent advances of antiviral drugs based on multispecific binding strategy
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Yang ZHOU, Shu-jing XU, Dang DING, Shuo WANG, Xin-yong LIU, Peng ZHAN*
Affiliations
  • Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
Published: 2023-08-12 doi: 10.16438/j.0513-4870.2023-0539
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To address the continuous emergence of drug-resistant strains of viruses and the outbreaks of novel virus infections, developing new antiviral drugs based on novel strategies has become an important and urgent research topic. In recent years, the rapidly developing multi-specific binding strategy has become a focus and been widely applied in antiviral. This review summarizes the recent progress of the multi-specific binding strategy in the antiviral field from the perspective of medicinal chemistry and discusses existing challenges as well as future opportunities for antiviral drug discovery.

virus  /  multispecific binding strategy  /  antiviral drug  /  medicinal chemistry  /  drug design
Yang ZHOU, Shu-jing XU, Dang DING, Shuo WANG, Xin-yong LIU, Peng ZHAN. Recent advances of antiviral drugs based on multispecific binding strategy[J]. Acta Pharmaceutica Sinica, 2023 , 58 (8) : 2203 -2217 . DOI: 10.16438/j.0513-4870.2023-0539
Year 2023 volume 58 Issue 8
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doi: 10.16438/j.0513-4870.2023-0539
  • Receive Date:2023-04-28
  • Online Date:2025-11-21
  • Published:2023-08-12
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  • Received:2023-04-28
  • Revised:2023-05-27
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    Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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