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Review considerations on the design and evaluation of the oral sensory features in pediatric medications
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Yan-zhe SUN, Duan-duan CONG, Ying GENG, Zhi-min YANG*
Acta Pharmaceutica Sinica | 2023, 58(11) : 3160 - 3164
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Acta Pharmaceutica Sinica | 2023, 58(11): 3160-3164
• Special Reports: Pharmaceutical Taste-Masking and Assessment Technologies •
Review considerations on the design and evaluation of the oral sensory features in pediatric medications
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Yan-zhe SUN, Duan-duan CONG, Ying GENG, Zhi-min YANG*
Affiliations
  • Centre for Drug Evaluation, National Medical Products Administration, Beijing 100076, China
Published: 2023-11-12 doi: 10.16438/j.0513-4870.2023-0488
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Recent years, China has released a series of policies to encourage drug research and development in pediatric populations, aiming to meet pediatric populations' medical needs. Because of the physical and psychological developmental characteristics, tolerance of aversive feelings when taking medications are different between pediatric population and adults. So pediatric populations are at a relatively higher risk of not taking medications as prescribed when the medication tasted unpleasant. Therefore, sound design and evaluation of oral sensory features have important clinical significance and value in developing pediatric medications. "Technical guidance for the design and evaluation of the oral sensory features of pediatric drugs (trial version) " was released in November 2022, by Centre for Drug Evaluation, National Medical Products Administration of China. Based on the guidance, this article will introduce the drafting background and review considerations, hoping to provide reference for the design and evaluation of oral sensory features, and promote drug developing in pediatric population.

pediatric medication  /  oral sensory feature  /  swallowability  /  palatability  /  design  /  evaluation
Yan-zhe SUN, Duan-duan CONG, Ying GENG, Zhi-min YANG. Review considerations on the design and evaluation of the oral sensory features in pediatric medications[J]. Acta Pharmaceutica Sinica, 2023 , 58 (11) : 3160 -3164 . DOI: 10.16438/j.0513-4870.2023-0488
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Article Info
doi: 10.16438/j.0513-4870.2023-0488
  • Receive Date：2023-04-22
  • Online Date：2025-11-21
  • Published：2023-11-12
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  • Received：2023-04-22
  • Revised：2023-08-08
Affiliations
    Centre for Drug Evaluation, National Medical Products Administration, Beijing 100076, China
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表12种不同金属材料的力学参数
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Number of
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Number of
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小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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