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An unprecedented pair of Z/E isomeric pyridinium compound from the aqueous extract of Aspongopus chinensis Dallas
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Chun-jiang WANG1, Can-xi YANG4, Ling-xi REN5, Shao LIU2, 3, *, Yue-ping JIANG2, 3, *
Acta Pharmaceutica Sinica | 2024, 59(1) : 166 - 169
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Acta Pharmaceutica Sinica | 2024, 59(1): 166-169
• Original Articles •
An unprecedented pair of Z/E isomeric pyridinium compound from the aqueous extract of Aspongopus chinensis Dallas
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Chun-jiang WANG1, Can-xi YANG4, Ling-xi REN5, Shao LIU2, 3, *, Yue-ping JIANG2, 3, *
Affiliations
  • 1. Department of Pharmacy, the Third Xiangya Hospital, Central South University, Changsha 410013, China
  • 2. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China
  • 3. Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
  • 4. College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
  • 5. School of Pharmaceutical Science, Jishou University, Jishou 416000, China
Published: 2024-01-12 doi: 10.16438/j.0513-4870.2023-0400
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A novel pair of Z/E isomeric compounds with unprecedented carbon skeleton were isolated from an aqueous extract of Aspongopus chinensis Dallas by macroporous resin, silica gel, and semi-preparative high performance liquid chromatography (HPLC). Their structures were identified by nuclear magnetic resonance (NMR), Infrared spectroscopy (IR), Mass spectroscopy (MS) and other spectroscopic methods as (Z)-3-(but-1″-en-1″-yl)-1-(2ʹ-hydroxyethyl)-4-propylpyridin-1-ium, namely aspongopyridine A, and (E)-3-(but-1″-en-1″-yl)-1-(2ʹ-hydroxyethyl)-4-propylpyridin-1-ium, namely aspongopyridine B, respectively. Besides, the anti-inflammatory, anti-tumor, acetylcholinesterase inhibition and butyrylcholinesterase inhibition activities of the compounds 1 and 2 were evaluated. The results showed that compounds 1 and 2 have no anti-inflammatory, anti-tumor, and butyrylcholinesterase inhibition activities instead of weak acetylcholinesterase inhibition activity.

Aspongopus chinensis Dallas  /  aqueous extract  /  pyridinium  /  unprecedented carbon skeleton  /  acetylcholinesterase inhibition activity
Chun-jiang WANG, Can-xi YANG, Ling-xi REN, Shao LIU, Yue-ping JIANG. An unprecedented pair of Z/E isomeric pyridinium compound from the aqueous extract of Aspongopus chinensis Dallas[J]. Acta Pharmaceutica Sinica, 2024 , 59 (1) : 166 -169 . DOI: 10.16438/j.0513-4870.2023-0400
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Year 2024 volume 59 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2023-0400
  • Receive Date：2023-04-03
  • Online Date：2025-11-28
  • Published：2024-01-12
Article Data
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History
  • Received：2023-04-03
  • Revised：2023-05-15
Affiliations
    1. Department of Pharmacy, the Third Xiangya Hospital, Central South University, Changsha 410013, China
    2. Department of Pharmacy, Xiangya Hospital, Central South University, Changsha 410008, China
    3. Institute for Rational and Safe Medication Practices, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha 410008, China
    4. College of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
    5. School of Pharmaceutical Science, Jishou University, Jishou 416000, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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