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Design of small molecules targeting molecular chaperone system: review and perspective
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Huang-liang SHU1, 2, Qi-dong YOU1, 2, *, Lei WANG1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(8) : 2035 - 2046
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Acta Pharmaceutica Sinica | 2023, 58(8): 2035-2046
Design of small molecules targeting molecular chaperone system: review and perspective
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Huang-liang SHU1, 2, Qi-dong YOU1, 2, *, Lei WANG1, 2, *
Affiliations
  • 1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
  • 2. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
Published: 2023-08-12 doi: 10.16438/j.0513-4870.2023-0395
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Molecular chaperone system, which mainly consist of heat shock proteins family and their cochaperones, is crucial for maintaining proteostasis in life. It assists in folding, maturation and ubiquitin-proteasome-mediated degradation of proteins, thus to play a key role in cell proliferation and apoptosis. Functional disorder of molecular chaperone system is highly relevant to occurrence and development of multiple diseases including cancers, autoimmune disease/inflammatory, infective diseases, neurodegenerative disease, etc. Therefore, molecular chaperone system has long been regarded as potential drug targets. In this review, we outline the progress in the design of small molecules targeting molecular chaperone system and analyze the features of small molecules with different mechanisms. Finally, we put forward expects about potential development directions for future drug design in this field.

molecular chaperone system  /  small molecule  /  drug design
Huang-liang SHU, Qi-dong YOU, Lei WANG. Design of small molecules targeting molecular chaperone system: review and perspective[J]. Acta Pharmaceutica Sinica, 2023 , 58 (8) : 2035 -2046 . DOI: 10.16438/j.0513-4870.2023-0395
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Year 2023 volume 58 Issue 8
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Article Info
doi: 10.16438/j.0513-4870.2023-0395
  • Receive Date：2023-04-02
  • Online Date：2025-11-21
  • Published：2023-08-12
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History
  • Received：2023-04-02
  • Revised：2023-04-21
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Affiliations
    1. Jiangsu Key Laboratory of Drug Design and Optimization, China Pharmaceutical University, Nanjing 210009, China
    2. Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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