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Preparation of 3D printed metoprolol tartrate chewable tablets and optimization of printing process
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Shan-shan WANG1, 2, Xiao-lu HAN2, En LIANG2, Cong-hui LI2, Chun-yan LIU3, Ming-yuan LI1, Zeng-ming WANG2, *, Peng YU1, *, Ai-ping ZHENG2, *
Acta Pharmaceutica Sinica | 2023, 58(9) : 2811 - 2817
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Acta Pharmaceutica Sinica | 2023, 58(9): 2811-2817
Preparation of 3D printed metoprolol tartrate chewable tablets and optimization of printing process
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Shan-shan WANG1, 2, Xiao-lu HAN2, En LIANG2, Cong-hui LI2, Chun-yan LIU3, Ming-yuan LI1, Zeng-ming WANG2, *, Peng YU1, *, Ai-ping ZHENG2, *
Affiliations
  • 1. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
  • 2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
  • 3. College of Pharmacy, North China University of Science and Technology, Tangshan 063210
Published: 2023-09-12 doi: 10.16438/j.0513-4870.2023-0143
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With the growing demand of personalized medicine for children, it is especially important to develop medicines for children. In this study, using metoprolol tartrate as model drug, we developed 3D printed chewable tablets suitable for children with automated dosage distribution using semi-solid extruded (SSE) 3D printing technology. Based on the quality by design concept, this study prepared a semi-solid material with good printability using gelatin as the substrate, constructed 3D models and printed tablets with the aid of computer-aided design. The printing parameters were optimized and determined as follows: print temperature of 35-37 ℃, print speed of 25 mm·s-1, fill rate of 15%, and number of outer profile layers of 2. Subsequently, the printing process and the quality uniformity of the tablets were verified, and a linear relationship between the dose and the number of model layers was obtained. Finally, 3D printed chewable tablets were superior in terms of appearance, dose accuracy and compliance compared with traditional split-dose commercially available tablets. In this study, 3D printed metoprolol tartrate chewable tablets with good performance were successfully prepared to address the personalized medication needs of pediatric patients.

3D printing  /  semi-solid extrusion  /  metoprolol tartrate  /  quality by design  /  personalized dose
Shan-shan WANG, Xiao-lu HAN, En LIANG, Cong-hui LI, Chun-yan LIU, Ming-yuan LI, Zeng-ming WANG, Peng YU, Ai-ping ZHENG. Preparation of 3D printed metoprolol tartrate chewable tablets and optimization of printing process[J]. Acta Pharmaceutica Sinica, 2023 , 58 (9) : 2811 -2817 . DOI: 10.16438/j.0513-4870.2023-0143
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Year 2023 volume 58 Issue 9
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Article Info
doi: 10.16438/j.0513-4870.2023-0143
  • Receive Date：2023-02-12
  • Online Date：2025-11-21
  • Published：2023-09-12
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History
  • Received：2023-02-12
  • Revised：2023-06-06
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Affiliations
    1. College of Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, China
    2. Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing 100850, China
    3. College of Pharmacy, North China University of Science and Technology, Tangshan 063210
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
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Genus		 种数
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Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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