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Two new ursane triterpenoids from Agastache rugosa (Fisch. et.Mey.) O. Kuntze
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Ya-ting REN1, Bei LI1, Jie MA1, Yu-huan LI2, Ying-da ZANG1, Chuang-jun LI1, *, Dong-ming ZHANG1, *
Acta Pharmaceutica Sinica | 2023, 58(6) : 1650 - 1654
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Acta Pharmaceutica Sinica | 2023, 58(6): 1650-1654
• Original Articles •
Two new ursane triterpenoids from Agastache rugosa (Fisch. et.Mey.) O. Kuntze
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Ya-ting REN1, Bei LI1, Jie MA1, Yu-huan LI2, Ying-da ZANG1, Chuang-jun LI1, *, Dong-ming ZHANG1, *
Affiliations
  • 1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-06-12 doi: 10.16438/j.0513-4870.2023-0067
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Two new ursane triterpenoids along with twelve known compounds were isolated from 80% ethanol extract of Agastache rugosa (Fisch. et. Mey.) O. Kuntze by using silica gel column, MCI column, ODS column and HPLC. The structures of the new compounds were identified as 2α, 3α-dihydroxy-24-nor-urs-4(23), 12(13)-dien-28-oic acid (1) and 2α, 3α-dihydroxy-24-nor-urs-4(23), 12(13), 20(30) -trien-28-oic acid (2) by HR-ESI-MS, NMR and ECD spectral data, named agasursacid A and agasursacid B. In addition, compounds 3, 4, 6, 8 showed anti-coxsackievirus B3 (CVB3) activities with a IC50 as 4.77, 1.59, 11.11 and 25.87 μmol·L-1, resepectively.

Agastache rugosa (Fisch.et.Mey.) O.Kuntze  /  chemical composition  /  ursane triterpenoid  /  anti-coxsackievirus B3 (CVB3) activities
Ya-ting REN, Bei LI, Jie MA, Yu-huan LI, Ying-da ZANG, Chuang-jun LI, Dong-ming ZHANG. Two new ursane triterpenoids from Agastache rugosa (Fisch. et.Mey.) O. Kuntze[J]. Acta Pharmaceutica Sinica, 2023 , 58 (6) : 1650 -1654 . DOI: 10.16438/j.0513-4870.2023-0067
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Year 2023 volume 58 Issue 6
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Article Info
doi: 10.16438/j.0513-4870.2023-0067
  • Receive Date：2023-01-27
  • Online Date：2025-11-21
  • Published：2023-06-12
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History
  • Received：2023-01-27
  • Revised：2023-02-20
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Affiliations
    1. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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