Home Journals Articles Updates About
CN
image
收藏切换
Polysaccharide of Balanophora involucrata Hook. f. attenuates cell ferroptosis in rats with experimental liver injury through SLC7A11/GPX4 pathway
收藏切换
PDF
Chen-chen JIA1, 2, 3, Rong YUE1, 2, 3, Chu-hua ZENG1, 3, Feng-qin LI3, Lu TANG3, Feng-jie WANG1, 2, 3, *
Acta Pharmaceutica Sinica | 2023, 58(9) : 2694 - 2699
Less
收藏切换
Acta Pharmaceutica Sinica | 2023, 58(9): 2694-2699
Polysaccharide of Balanophora involucrata Hook. f. attenuates cell ferroptosis in rats with experimental liver injury through SLC7A11/GPX4 pathway
Full
Chen-chen JIA1, 2, 3, Rong YUE1, 2, 3, Chu-hua ZENG1, 3, Feng-qin LI3, Lu TANG3, Feng-jie WANG1, 2, 3, *
Affiliations
  • 1. Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases (Hubei Minzu University), Enshi 445000, China
  • 2. Minda Hospital of Hubei Minzu University, Enshi 445000, China
  • 3. Medical School, Hubei Minzu University, Enshi 445000, China
Published: 2023-09-12 doi: 10.16438/j.0513-4870.2023-0058
Outline
收藏切换

Polysaccharide of Balanophora involucrata Hook. f. (BPS), the major component of Balanophora involucrata Hook. f., was confirmed the protective effect on liver injury in our previous study. This research aimed to investigate the protective mechanism of BPS on experimental liver injury by attenuating cell ferroptosis through modulating solute carrier family 7 member 11/glutathione peroxidase 4 (SLC7A11/GPX4) pathway. The animal experiment was approved by the Experimental Animal Ethical Committee of Hubei Minzu University and all rats had received human care in compliance with the institutional animal care guidelines. Rats were given intraperitoneal injection of (D-galactosamine, D-GalN) solution (800 mg·kg-1) one time to establish the acute liver injury model. The results showed aspartate amino transferase (AST), alanine aminotransferase (ALT) and 4-hydroxynonenal (4-HNE) levels in serum were decreased, and the contents of reactive oxygen species (ROS), Fe2+, malondialdehyde (MDA) and lipid peroxide (LPO) in liver tissues also decreased and glutathione (GSH) level increased after BPS administration with 200 mg·kg-1. Besides, BPS reduced iron deposition and increased the expression of SLC7A11 and GPX4 proteins in liver tissue. In conclusion, BPS ameliorated experimental liver injury by alleviating cell ferroptosis through SLC7A11/GPX4 pathway. The present study pointed to the possibility of utilizing BPS for protection against liver injury in clinic.

Balanophora involucrata Hook. f.  /  experimental liver injury  /  SLC7A11  /  GPX4  /  ferroptosis
Chen-chen JIA, Rong YUE, Chu-hua ZENG, Feng-qin LI, Lu TANG, Feng-jie WANG. Polysaccharide of Balanophora involucrata Hook. f. attenuates cell ferroptosis in rats with experimental liver injury through SLC7A11/GPX4 pathway[J]. Acta Pharmaceutica Sinica, 2023 , 58 (9) : 2694 -2699 . DOI: 10.16438/j.0513-4870.2023-0058
Appendix
Less
Year 2023 volume 58 Issue 9
PDF
166
63
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2023-0058
  • Receive Date：2023-01-17
  • Online Date：2025-11-21
  • Published：2023-09-12
Article Data
Affiliations
History
  • Received：2023-01-17
  • Revised：2023-03-17
Funding
Affiliations
    1. Hubei Provincial Key Laboratory of Occurrence and Intervention of Rheumatic Diseases (Hubei Minzu University), Enshi 445000, China
    2. Minda Hospital of Hubei Minzu University, Enshi 445000, China
    3. Medical School, Hubei Minzu University, Enshi 445000, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2023-0058
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House