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Non clinical pharmacodynamic evaluation system of high-altitude hypoxic brain injury
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Meng-yao LIU1, Chun-yang ZHAO2, Nian-ying SHANG1, Qing-li WANG2, *, Ying PENG1, *
Acta Pharmaceutica Sinica | 2023, 58(6) : 1515 - 1520
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Acta Pharmaceutica Sinica | 2023, 58(6): 1515-1520
• Reviews •
Non clinical pharmacodynamic evaluation system of high-altitude hypoxic brain injury
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Meng-yao LIU1, Chun-yang ZHAO2, Nian-ying SHANG1, Qing-li WANG2, *, Ying PENG1, *
Affiliations
  • 1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Center for Drug Evaluation, National Medical Product Administration, Beijing 100022, China
Published: 2023-06-12 doi: 10.16438/j.0513-4870.2022-1393
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The air at high altitude is thin and belongs to the environment of low temperature, low oxygen and low pressure. The human brain is the most sensitive to hypoxia. Hypoxia will cause dysfunction of the central nervous system, resulting in high-altitude hypoxic brain injury, including mild high altitude headache and more destructive high altitude cerebral edema (HACE). Recently, with more and more people work and live in high altitude areas, the development of high-altitude hypoxic brain injury drugs would produce great economic value and social significance. Non clinical pharmacodynamic evaluation is the basic of drug development, which plays a key role in improving the success rate of clinical transformation and reducing the risk of clinical research. This review summarizes the cell models and animal models, and the evaluation indicators usually used to explore the candidates of high-altitude hypoxic brain injury. We aim at establishing a standardized non clinical efficacy evaluation system for high altitude hypoxic encephalopathy, and provide a standardized reference for drug development in hypoxic encephalopathy at high altitude at nonclinical stage.

high altitude hypoxic brain injury  /  non-clinical efficacy  /  drug discovery  /  cell model  /  animal model
Meng-yao LIU, Chun-yang ZHAO, Nian-ying SHANG, Qing-li WANG, Ying PENG. Non clinical pharmacodynamic evaluation system of high-altitude hypoxic brain injury[J]. Acta Pharmaceutica Sinica, 2023 , 58 (6) : 1515 -1520 . DOI: 10.16438/j.0513-4870.2022-1393
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Article Info
doi: 10.16438/j.0513-4870.2022-1393
  • Receive Date：2022-12-16
  • Online Date：2025-11-21
  • Published：2023-06-12
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History
  • Received：2022-12-16
  • Revised：2023-01-13
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Affiliations
    1. Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Center for Drug Evaluation, National Medical Product Administration, Beijing 100022, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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