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Identification of constituents in vitro and blood-absorbed ingredients of protective effect on acute liver injury from Yin Chen Hao decoction based on UPLC-QTOF/MS
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Yi-qing YAO, Qi CAO, Xuan WANG, Hui-lin MA, Yu-miao CHEN, Si-yi ZHAO, Min-xuan GUO, Jia-meng HU, Dong-yao WANG*, Di-ya LÜ*
Acta Pharmaceutica Sinica | 2023, 58(5) : 1173 - 1180
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Acta Pharmaceutica Sinica | 2023, 58(5): 1173-1180
• Special Reports: Active Ingredients and Mechanism of Action of Traditional Chinese Medicine •
Identification of constituents in vitro and blood-absorbed ingredients of protective effect on acute liver injury from Yin Chen Hao decoction based on UPLC-QTOF/MS
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Yi-qing YAO, Qi CAO, Xuan WANG, Hui-lin MA, Yu-miao CHEN, Si-yi ZHAO, Min-xuan GUO, Jia-meng HU, Dong-yao WANG*, Di-ya LÜ*
Affiliations
  • School of Pharmacy, Naval Medical University, Shanghai 200433, China
Published: 2023-05-12 doi: 10.16438/j.0513-4870.2022-1139
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To identify the active constituents in vitro and blood-absorbed ingredients in vivo from Yin Chen Hao decoction provides scientific evidence for probing its prevention and treatment mechanism on acute liver injury. An ultrahigh performance liquid chromatography quadrupole-time of flight-mass spectrometry (UPLC-QTOF/MS) method was applied for analysis of Yin Chen Hao decoction and the serum samples of mice with con-A induced acute liver injury after preventive oral administration for 14 days (the use of all laboratory animals in this study was approved by the Ethics Committee of the Naval Medical University, 19YF1459400). A total of 90 chemical constituents were identified from Yin Chen Hao decoction, mainly were flavonoids, terpenoids, tannins, quinones. 5 prototype compounds were identified in the serum, including chrysophanol, deoxyrhapontin-8-O-gallate, mussaenosidic acid, herniarin, emodin. The established UPLC-QTOF/MS method could efficiently and sensitively identify the constituents in vitro and blood-absorbed ingredients of Yin Chen Hao decoction, primarily clarify the material basis of its hepatoprotective effect, and provided a scientific basis for the quality marker selection and the pharmacodynamic material basis research on the decoction.

UPLC-QTOF/MS  /  chemical constituent  /  blood-absorbed ingredient  /  Yin Chen Hao decoction  /  acute liver injury  /  hepatoprotective effect
Yi-qing YAO, Qi CAO, Xuan WANG, Hui-lin MA, Yu-miao CHEN, Si-yi ZHAO, Min-xuan GUO, Jia-meng HU, Dong-yao WANG, Di-ya LÜ. Identification of constituents in vitro and blood-absorbed ingredients of protective effect on acute liver injury from Yin Chen Hao decoction based on UPLC-QTOF/MS[J]. Acta Pharmaceutica Sinica, 2023 , 58 (5) : 1173 -1180 . DOI: 10.16438/j.0513-4870.2022-1139
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Article Info
doi: 10.16438/j.0513-4870.2022-1139
  • Receive Date：2022-10-30
  • Online Date：2025-11-21
  • Published：2023-05-12
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  • Received：2022-10-30
  • Revised：2023-04-15
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    School of Pharmacy, Naval Medical University, Shanghai 200433, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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