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Identification of the metabolites from co-cultures of marine Streptomyces sp. IMB18-531 and Cladosporium sp. IMB19-099
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Sha-sha LI1, Qin LI1, 2, Yi-ming LI1, Yue SHANG1, Hong-wei HE1, Shu-zhen CHEN1, Ji-cheng SHU2, *, Mao-luo GAN1, *
Acta Pharmaceutica Sinica | 2023, 58(4) : 967 - 974
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Acta Pharmaceutica Sinica | 2023, 58(4): 967-974
• Original Articles •
Identification of the metabolites from co-cultures of marine Streptomyces sp. IMB18-531 and Cladosporium sp. IMB19-099
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Sha-sha LI1, Qin LI1, 2, Yi-ming LI1, Yue SHANG1, Hong-wei HE1, Shu-zhen CHEN1, Ji-cheng SHU2, *, Mao-luo GAN1, *
Affiliations
  • 1. Laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. Key Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
Published: 2023-04-12 doi: 10.16438/j.0513-4870.2022-1130
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A new siderophore chelate (1) and 8 known compounds were identified from the liquid co-cultures of the marine-derived Streptomyces sp. IMB18-531 and Cladosporium sp. IMB19-099 by a combination of chromatography methods, including C18 reversed-phase medium pressure chromatography, gel column chromatography and HPLC. Their structures were determined by spectroscopic analysis and chemical methods as aluminioxamine E (1), desferrioxamine E (2), ferrioxamine E (3), terragine E (4), capsimicin (5), cyclo(L-prolinyl-L-tyrosine) (6), anthranilic acid (7), (Z)-14-methylpentadec-9-enoic acid (8), and (Z)-hexadec-8-enoic acid (9). Compound 2 showed inhibitory activities against the expression of liver fibrosis related genes COL1A1, MMP2, and TIMP2. Compounds 5, 8, and 9 displayed antibacterial activities against methicillin-resistant Staphylococcus aureus, S. epidermidis and Bacillus subtilis, with MICs of 16-64 μg·mL-1. Compound 5 showed cytotoxicities against human pancreatic cancer MIA Paca-2 and human colon cancer HT-29 cell lines with IC50 of 2.9 and 6.3 μmol·L-1, respectively.

marine microorganism  /  co-culture  /  siderophore  /  anti-hepatic fibrosis  /  desferrioxamine E
Sha-sha LI, Qin LI, Yi-ming LI, Yue SHANG, Hong-wei HE, Shu-zhen CHEN, Ji-cheng SHU, Mao-luo GAN. Identification of the metabolites from co-cultures of marine Streptomyces sp. IMB18-531 and Cladosporium sp. IMB19-099[J]. Acta Pharmaceutica Sinica, 2023 , 58 (4) : 967 -974 . DOI: 10.16438/j.0513-4870.2022-1130
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Year 2023 volume 58 Issue 4
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Article Info
doi: 10.16438/j.0513-4870.2022-1130
  • Receive Date：2022-10-28
  • Online Date：2025-11-21
  • Published：2023-04-12
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History
  • Received：2022-10-28
  • Revised：2022-12-28
Funding
Affiliations
    1. Laboratory for Screening New Microbial Drugs, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. Key Laboratory of Modern Preparation of Traditional Chinese Medicines, Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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