Home Journals Articles Updates About
CN
image
收藏切换
Physiological pharmacokinetic model of children and its application of modeling software
收藏切换
PDF
Xu ZHOU, Yuan-yuan WEI, Tao MA, Yue-zhou TANG, Yun-jie DANG*, De-ying CAO*
Acta Pharmaceutica Sinica | 2023, 58(2) : 320 - 329
Less
收藏切换
Acta Pharmaceutica Sinica | 2023, 58(2): 320-329
• Reviews •
Physiological pharmacokinetic model of children and its application of modeling software
Full
Xu ZHOU, Yuan-yuan WEI, Tao MA, Yue-zhou TANG, Yun-jie DANG*, De-ying CAO*
Affiliations
  • School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
Published: 2023-02-12 doi: 10.16438/j.0513-4870.2022-1124
Outline
收藏切换

Developmental changes in children can affect drug disposition and clinical effects. A physiologically-based pharmacokinetic (PBPK) model is a mathematical model that can be used to predict blood drug concentrations in children and gain insight into age-dependent physiological differences in drug disposition impact. Pediatric PBPK (P-PBPK) models have attracted attention over the past decade. With the concerted efforts of academia, pharmaceutical companies, and regulatory agencies, there are more and more examples of pediatric clinical studies using PBPK models. Nevertheless, the number of P-PBPK models and their predictive performance still lag behind adult models. By referring to the literature, we study the process of children adapting to adult absorption, distribution, metabolism, and excretion (ADME) parameters and analyze the general principles of P-PBPK model establishment. In addition, we summarize the functions and application examples of commonly used P-PBPK modeling software to provide a basis for the rational application of modeling software.

drug disposition  /  prediction  /  physiology based pharmacokinetic model  /  pediatric physiologic pharmacokinetic model  /  modeling software
Xu ZHOU, Yuan-yuan WEI, Tao MA, Yue-zhou TANG, Yun-jie DANG, De-ying CAO. Physiological pharmacokinetic model of children and its application of modeling software[J]. Acta Pharmaceutica Sinica, 2023 , 58 (2) : 320 -329 . DOI: 10.16438/j.0513-4870.2022-1124
Appendix
Less
Year 2023 volume 58 Issue 2
PDF
226
98
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-1124
  • Receive Date：2022-10-25
  • Online Date：2025-11-21
  • Published：2023-02-12
Article Data
Affiliations
History
  • Received：2022-10-25
  • Revised：2022-12-22
Funding
Affiliations
    School of Pharmacy, Hebei Medical University, Shijiazhuang 050017, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-1124
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House