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Research progress on the development of human neutrophil elastase inhibitors
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Zhong-wei WANG, Hui WEN, Yu-chen WANG, Hua-qing CUI*
Acta Pharmaceutica Sinica | 2023, 58(4) : 909 - 918
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Acta Pharmaceutica Sinica | 2023, 58(4): 909-918
Research progress on the development of human neutrophil elastase inhibitors
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Zhong-wei WANG, Hui WEN, Yu-chen WANG, Hua-qing CUI*
Affiliations
  • Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-04-12 doi: 10.16438/j.0513-4870.2022-1116
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Human neutrophil elastase (hNE) is a serine proteolytic enzyme mainly distributed in neutrophils. When the balance between anti-hNE protein and hNE is broken, excessive release of hNE can cause the occurrence of various diseases. Therefore, inhibition of hNE is a promising therapeutic strategy. In this paper, the structure, action mechanism, physiological function of hNE and the development of hNE inhibitors were briefly summarized, in order to provide information for the related research.

human neutrophil elastase  /  human neutrophil elastase mechanism  /  human neutrophil elastase physiological effect  /  human neutrophil elastase inhibitor
Zhong-wei WANG, Hui WEN, Yu-chen WANG, Hua-qing CUI. Research progress on the development of human neutrophil elastase inhibitors[J]. Acta Pharmaceutica Sinica, 2023 , 58 (4) : 909 -918 . DOI: 10.16438/j.0513-4870.2022-1116
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Article Info
doi: 10.16438/j.0513-4870.2022-1116
  • Receive Date：2022-10-17
  • Online Date：2025-11-21
  • Published：2023-04-12
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  • Received：2022-10-17
  • Revised：2022-12-09
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    Beijing Key Laboratory of Active Substance Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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