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Research progress in bioanalysis and pharmacokinetics of liposome nanomedicine
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Yi LIU1, Yu-jie ZHANG1, Zi-yu WANG2, Jian-song YOU2, Lei YIN1, *, Mei-yun SHI1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(4) : 834 - 843
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Acta Pharmaceutica Sinica | 2023, 58(4): 834-843
• Special Reports: Study on Pharmacokinetics of Nanomedicine •
Research progress in bioanalysis and pharmacokinetics of liposome nanomedicine
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Yi LIU1, Yu-jie ZHANG1, Zi-yu WANG2, Jian-song YOU2, Lei YIN1, *, Mei-yun SHI1, 2, *
Affiliations
  • 1. School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, China
  • 2. Aim Honesty Biopharmaceutical Co. Ltd., Dalian 116100, China
Published: 2023-04-12 doi: 10.16438/j.0513-4870.2022-1085
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Liposome nanomedicine is a new drug preparation with nano scale, which is encapsulated by lipid bilayer vesicle structure. As a drug delivery carrier, liposome has many advantages such as good biocompatibility, biodegradation in vivo and strong targeting. The application of liposome nano drug delivery system can improve the pharmacokinetic behavior and efficacy of some drugs in vivo to a certain extent, and reduce toxic and side effects. After liposome nanomedicine enter into the body, free drugs will be released, so there will be loaded drugs and free drugs in the body. Loaded drugs are drug repositories, free drugs are related to their efficacy and adverse reactions. Therefore, the pharmacokinetics study of liposomes should focus on both loaded drugs and free drugs. Quantitative analysis of free drugs, liposome particles and their materials is a big challenge. The bioanalysis and pharmacokinetics of liposome nanomedicines will be introduced and discussed in this review. We hope this review will provide a reference for the development of liposome nanomedicine.

liposome nanomedicine  /  pretreatment method  /  release drug  /  biological analytical method  /  pharmacokinetics
Yi LIU, Yu-jie ZHANG, Zi-yu WANG, Jian-song YOU, Lei YIN, Mei-yun SHI. Research progress in bioanalysis and pharmacokinetics of liposome nanomedicine[J]. Acta Pharmaceutica Sinica, 2023 , 58 (4) : 834 -843 . DOI: 10.16438/j.0513-4870.2022-1085
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Article Info
doi: 10.16438/j.0513-4870.2022-1085
  • Receive Date：2022-09-29
  • Online Date：2025-11-21
  • Published：2023-04-12
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History
  • Received：2022-09-29
  • Revised：2023-03-02
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Affiliations
    1. School of Life and Pharmaceutical Sciences, Dalian University of Technology, Panjin 124221, China
    2. Aim Honesty Biopharmaceutical Co. Ltd., Dalian 116100, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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