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The biological principle of "Biao Ben Jian Zhi"
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Rui LI1, Xiu-ping GUO2, Yan-xing HAN2, Lu-lu WANG1, Jian-dong JIANG1, 2, *
Acta Pharmaceutica Sinica | 2023, 58(2) : 351 - 359
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Acta Pharmaceutica Sinica | 2023, 58(2): 351-359
• Opinion and Academic Contention •
The biological principle of "Biao Ben Jian Zhi"
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Rui LI1, Xiu-ping GUO2, Yan-xing HAN2, Lu-lu WANG1, Jian-dong JIANG1, 2, *
Affiliations
  • 1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  • 2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-02-12 doi: 10.16438/j.0513-4870.2022-1084
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Along with the progress of pharmaceutical science in the past century, the theme of pharmacology has gone through pseudo agent scheme, to ligand-receptor model, and then to the theory of targeted therapy today. Due to the success of drug R&D, current drug research keeps its focus mainly on drugs with single target and precise treatment, in which the molecular mechanism is relatively clear but the therapeutic efficacy is often limited. Thus, there is a big space for exploration in the field of pharmacology. In the past 30 years, several novel chemical drugs, originated from traditional Chinese medicine, have been identified and then used in clinic, provoking a strong interest to explore new theory for pharmacology, of which the term of "Biao Ben Jian Zhi" (treating diseases by directing symptoms and root causes) has demonstrated a promising nature. We consider this concept useful for future drug discovery, drug design and clinical therapy. In this review, example drugs such as berberine, metformin and azvudine, are discussed, and "drug Cloud" (dCloud) model is introduced to elaborate the mechanism of treating diseases by directing symptoms and root causes of diseases.

pharmacology  /  complex system of drugs  /  Biao Ben Jian Zhi  /  berberine  /  drug Cloud
Rui LI, Xiu-ping GUO, Yan-xing HAN, Lu-lu WANG, Jian-dong JIANG. The biological principle of "Biao Ben Jian Zhi"[J]. Acta Pharmaceutica Sinica, 2023 , 58 (2) : 351 -359 . DOI: 10.16438/j.0513-4870.2022-1084
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Article Info
doi: 10.16438/j.0513-4870.2022-1084
  • Receive Date：2022-09-29
  • Online Date：2025-11-21
  • Published：2023-02-12
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  • Received：2022-09-29
  • Revised：2022-11-09
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Affiliations
    1. Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
    2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数
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Number of
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Number of
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鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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