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Research progress of cyclic peptide synthesis strategy and its application in new drug development
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Si-jia SU1, Qing-wei BU1, Chun-quan SHENG1, 2, *, Shan-chao WU2, *
Acta Pharmaceutica Sinica | 2023, 58(3) : 629 - 638
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Acta Pharmaceutica Sinica | 2023, 58(3): 629-638
• Reviews •
Research progress of cyclic peptide synthesis strategy and its application in new drug development
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Si-jia SU1, Qing-wei BU1, Chun-quan SHENG1, 2, *, Shan-chao WU2, *
Affiliations
  • 1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
  • 2. Second Military Medical University, Shanghai 200433, China
Published: 2023-03-12 doi: 10.16438/j.0513-4870.2022-0956
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Protein-protein interaction (PPI) plays an important role in the regulation of life. Most of the PPI interfaces are large and discontinuous, and it is difficult for small molecules to specifically bind to them. Peptides are critical in PPI surface interactions due to their higher affinity and specificity. However, peptides have some defects such as easy hydrolysis by protease and poor membrane permeability. Due to good biocompatibility and chemical diversity, cyclic peptides play an important role in drug discovery. Therefore, the development of efficient cyclic peptide construction methods has become a frontier issue in peptide drug research. In recent years, a series of new progresses have been made in the synthesis strategy and the application of cyclic peptides, providing powerful technical tools for the research and development of cyclic peptide drugs. In this review, the synthesis strategies of cyclic peptides and their application will be reviewed from four aspects: synthesis strategies, property improvement, biological activity and prospect.

peptide  /  cyclic peptide  /  synthetic strategy  /  improve property  /  biological activity
Si-jia SU, Qing-wei BU, Chun-quan SHENG, Shan-chao WU. Research progress of cyclic peptide synthesis strategy and its application in new drug development[J]. Acta Pharmaceutica Sinica, 2023 , 58 (3) : 629 -638 . DOI: 10.16438/j.0513-4870.2022-0956
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Year 2023 volume 58 Issue 3
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Article Info
doi: 10.16438/j.0513-4870.2022-0956
  • Receive Date：2022-08-03
  • Online Date：2025-11-21
  • Published：2023-03-12
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  • Received：2022-08-03
  • Revised：2022-09-13
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    1. School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, China
    2. Second Military Medical University, Shanghai 200433, China
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Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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