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Investigation of metabolites of synthetic cannabinoid 4CN-MDMB-BUTINAC in vitro by liquid-chromatography-quadruple/orbitrap mass spectrometry
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Shan-hui ZHOU1, Yu XU2, Zhen-feng YU1, Xing KE1, Yi-lei FAN1, *
Acta Pharmaceutica Sinica | 2022, 57(12) : 3653 - 3659
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Acta Pharmaceutica Sinica | 2022, 57(12): 3653-3659
• Original Articles •
Investigation of metabolites of synthetic cannabinoid 4CN-MDMB-BUTINAC in vitro by liquid-chromatography-quadruple/orbitrap mass spectrometry
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Shan-hui ZHOU1, Yu XU2, Zhen-feng YU1, Xing KE1, Yi-lei FAN1, *
Affiliations
  • 1. Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou 310053, China
  • 2. Key Laboratory of Drug Monitoring and Control of Zhejiang Province, National Anti-Drug Laboratory Zhejiang Regional Center, Hangzhou 310053, China
Published: 2022-12-12 doi: 10.16438/j.0513-4870.2022-0924
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To investigate the metabolites of a new synthetic cannabinoid 3, 3-dimethyl-2-[1-(4-cyanobutyl)indazole-3-formamimino]methyl butyrate (4CN-MDMB-BUTINACA) in vitro, a human liver microsome incubation model was established to analyze the metabolic biotransformation of synthetic cannabinoids using ultra-high performance liquid chromatography coupled to quadrupole-orbitrap high-resolution mass spectrometry. Nontarget metabolomic results showed that the metabolites of 4CN-MDMB-BUTINACA included hydroxylation, ester hydrolysis, ester hydrolysis with hydroxylation reaction, pentane oxidation and ester hydrolysis with pentane oxidation reaction, among which M1-a, M2 and M4 were potential metabolic markers. The research results provide a theoretical basis and technical support for the biomonitoring and metabolic characterisation of the cannabinoid 4CN-MDMB-BUTINACA.

synthetic cannabinoid  /  liver microsome  /  metabolite  /  metabolic pathway
Shan-hui ZHOU, Yu XU, Zhen-feng YU, Xing KE, Yi-lei FAN. Investigation of metabolites of synthetic cannabinoid 4CN-MDMB-BUTINAC in vitro by liquid-chromatography-quadruple/orbitrap mass spectrometry[J]. Acta Pharmaceutica Sinica, 2022 , 57 (12) : 3653 -3659 . DOI: 10.16438/j.0513-4870.2022-0924
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Article Info
doi: 10.16438/j.0513-4870.2022-0924
  • Receive Date：2022-07-28
  • Online Date：2025-12-24
  • Published：2022-12-12
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History
  • Received：2022-07-28
  • Revised：2022-09-29
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Affiliations
    1. Key Laboratory of Drug Prevention and Control Technology of Zhejiang Province, Zhejiang Police College, Hangzhou 310053, China
    2. Key Laboratory of Drug Monitoring and Control of Zhejiang Province, National Anti-Drug Laboratory Zhejiang Regional Center, Hangzhou 310053, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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