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Progress on targets and therapeutic drugs for pancreatic cancer
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Hong YANG, Wan LI, Sha LI, Li-wen REN, Yi-zhi ZHANG, Yi-hui YANG, Bin-bin GE, Xiang-jin ZHENG, Jin-yi LIU, Sen ZHANG, Guan-hua DU, Jin-hua WANG*
Acta Pharmaceutica Sinica | 2023, 58(1) : 9 - 20
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Acta Pharmaceutica Sinica | 2023, 58(1): 9-20
Progress on targets and therapeutic drugs for pancreatic cancer
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Hong YANG, Wan LI, Sha LI, Li-wen REN, Yi-zhi ZHANG, Yi-hui YANG, Bin-bin GE, Xiang-jin ZHENG, Jin-yi LIU, Sen ZHANG, Guan-hua DU, Jin-hua WANG*
Affiliations
  • Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2023-01-12 doi: 10.16438/j.0513-4870.2022-0824
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Pancreatic cancer is a highly malignant tumor with a poor prognosis. It is very hard to treat pancreatic cancers for their high heterogeneity, complex tumor microenvironment, and drug resistance. Currently, gemcitabine plus nab-paclitaxel, capecitabine and FOLFIRINOX are standard chemotherapy for resectable or advanced metastatic pancreatic cancer. Considering the limited efficacy and toxic side effects of chemotherapy, targeted and immune drugs have gradually attracted attention and made some progress. In this article, we systematically reviewed the chemotherapeutic drugs, targets and related targeted drugs, and immunotherapy drugs for pancreatic cancer.

pancreatic cancer  /  chemotherapy  /  drug target  /  targeted therapy  /  immunotherapy
Hong YANG, Wan LI, Sha LI, Li-wen REN, Yi-zhi ZHANG, Yi-hui YANG, Bin-bin GE, Xiang-jin ZHENG, Jin-yi LIU, Sen ZHANG, Guan-hua DU, Jin-hua WANG. Progress on targets and therapeutic drugs for pancreatic cancer[J]. Acta Pharmaceutica Sinica, 2023 , 58 (1) : 9 -20 . DOI: 10.16438/j.0513-4870.2022-0824
Year 2023 volume 58 Issue 1
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Article Info
doi: 10.16438/j.0513-4870.2022-0824
  • Receive Date:2022-07-05
  • Online Date:2025-11-21
  • Published:2023-01-12
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  • Received:2022-07-05
  • Revised:2022-08-10
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    Beijing Key Laboratory of Drug Target Identification and Drug Screening, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
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表12种不同金属材料的力学参数

Family
属数
Number of
genus
种数
Number of
species
占总种数比例
Percentage of
total species (%)

Genus
种数
Number of
species
占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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