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Exploring the safe and rational use of Epimedii Folium based on the evolution of efficacy/toxicity records in ancient and modern literature
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Yuan GAO1, Jia-bo WANG1, Xiao-he XIAO2, 3, *, Zhao-fang BAI2, 3, *
Acta Pharmaceutica Sinica | 2023, 58(2) : 246 - 257
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Acta Pharmaceutica Sinica | 2023, 58(2): 246-257
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Exploring the safe and rational use of Epimedii Folium based on the evolution of efficacy/toxicity records in ancient and modern literature
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Yuan GAO1, Jia-bo WANG1, Xiao-he XIAO2, 3, *, Zhao-fang BAI2, 3, *
Affiliations
  • 1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
  • 2. China Military Institute of Chinese Medicine, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China
  • 3. Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China
Published: 2023-02-12 doi: 10.16438/j.0513-4870.2022-0801
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Epimedii Folium is a traditional non-toxic Chinese herbal medicine. However, liver injury caused by Chinese herb preparations, including Epimedii Folium, is frequently reported over the years. Based on ancient and modern literature, this paper systematically summarized and analyzed the safe application of Epimedii Folium from the perspectives of varieties, processing methods, clinical adverse reactions, pharmacological effects and toxic mechanism. Combined with our team work, we build the comprehensive prevention and control system "human-drug-application", for the safe and rational application of Epimedii Folium. This study is expected to provide support for scientific evaluation and precise prevention and control of the safety risk of Epimedii Folium.

Epimedii Folium  /  toxicity  /  security  /  disease-syndrome-based toxicology  /  the rational use of drugs
Yuan GAO, Jia-bo WANG, Xiao-he XIAO, Zhao-fang BAI. Exploring the safe and rational use of Epimedii Folium based on the evolution of efficacy/toxicity records in ancient and modern literature[J]. Acta Pharmaceutica Sinica, 2023 , 58 (2) : 246 -257 . DOI: 10.16438/j.0513-4870.2022-0801
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Article Info
doi: 10.16438/j.0513-4870.2022-0801
  • Receive Date：2022-06-30
  • Online Date：2025-11-21
  • Published：2023-02-12
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History
  • Received：2022-06-30
  • Revised：2022-08-09
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Affiliations
    1. School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China
    2. China Military Institute of Chinese Medicine, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China
    3. Senior Department of Hepatology, the Fifth Medical Center of PLA General Hospital, Beijing 100039, China
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表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
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