Home Journals Articles Updates About
CN
image
收藏切换
Pharmacodynamic study of chiral oxiracetam on neuroprotection and anti-dementia
收藏切换
PDF
Ling WANG, Shao-feng XU, Nan FENG, Wei-ping WANG, Xiao-liang WANG*
Acta Pharmaceutica Sinica | 2022, 57(9) : 2738 - 2742
Less
收藏切换
Acta Pharmaceutica Sinica | 2022, 57(9): 2738-2742
• Original Articles •
Pharmacodynamic study of chiral oxiracetam on neuroprotection and anti-dementia
Full
Ling WANG, Shao-feng XU, Nan FENG, Wei-ping WANG, Xiao-liang WANG*
Affiliations
  • Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
Published: 2022-09-12 doi: 10.16438/j.0513-4870.2022-0741
Outline
收藏切换

To compare the neuroprotective and anti-dementia pharmacological effects of chiral oxiracetam, glutamate and calcium ions were used to establish neuronal injury models in vitro, and the protective effects of chiral oxiracetam on primary neurons were assayed by MTT. Permanent bilateral common carotid artery occlusion (2-VO)-induced rats were randomly divided into sham group, model group, galantamine 3 mg‧kg-1 group, oxiracetam groups (30, 100 and 200 mg‧kg-1), S-oxiracetam groups (30, 100 and 200 mg‧kg-1) and R-oxiracetam 200 mg‧kg-1 group. The animal experiments in the present study were performed in accordance with the Ethical Guidelines of the Laboratory Animal Welfare Ethical Committee of Peking Union Medical College. Morris water maze and step-down test were applied to evaluate the cognitive dysfunction induced by cerebral hypoperfusion in rats. Oxiracetam, S-oxiracetam and R-oxiracetam exerted protective effects on primary neuronal damage caused by various stimuli, and oxiracetam and S-oxiracetam showed better neuro-protective effects. Morris water maze and step-down results showed that oxiracetam, S-oxiracetam and R-oxiracetam improved the cognition of 2-VO rats. In summary, S-oxiracetam exerted a better neuro-protective effect than oxiracetam and R-oxiracetam.

oxiracetam  /  optical isomer  /  brain protection  /  learning and memory  /  vascular dementia
Ling WANG, Shao-feng XU, Nan FENG, Wei-ping WANG, Xiao-liang WANG. Pharmacodynamic study of chiral oxiracetam on neuroprotection and anti-dementia[J]. Acta Pharmaceutica Sinica, 2022 , 57 (9) : 2738 -2742 . DOI: 10.16438/j.0513-4870.2022-0741
Appendix
Less
Year 2022 volume 57 Issue 9
PDF
173
68
Cite this Article
BibTeX
Article Info
doi: 10.16438/j.0513-4870.2022-0741
  • Receive Date：2022-06-16
  • Online Date：2025-12-24
  • Published：2022-09-12
Article Data
Affiliations
History
  • Received：2022-06-16
  • Revised：2022-07-13
Funding
Affiliations
    Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
References
Share
https://castjournals.cast.org.cn/joweb/yxxb/EN/10.16438/j.0513-4870.2022-0741
Share to
QR

Scan QR to access full text

Cite this article
BibTeX
Citations
表12种不同金属材料的力学参数
科
Family		 属数
Number of
genus		 种数
Number of
species		 占总种数比例
Percentage of
total species (%)		 属
Genus		 种数
Number of
species		 占总种数比例
Percentage of total
species (%)
鹅膏菌科Amanitaceae 2 11 5.26 鹅膏菌属 Amanita 10 4.78
小菇科 Mycenaceae 2 12 5.74 丝盖伞属 Inocybe 5 2.39
多孔菌科 Polyporaceae 8 14 6.70 蜡蘑属 Laccaria 5 2.39
红菇科 Russulaceae 3 23 11.00 小皮伞属 Marasmius 6 2.87
小菇属 Mycena 11 5.26
光柄菇属 Pluteus 5 2.39
红菇属 Russula 17 8.13
栓菌属 Trametes 5 2.39
关闭全屏
  • BibTeX
  • EndNote
  • RefWorks
  • TxT
Links
Articles
Latest Articles
Most Read
Collections
Updates
Events
News
Multimedia
About
About Us
Contact
No. 86 Xueyuan South Road, Haidian District, Beijing
100081
010-62199257
qkjq@cast.org.cn

Copyright © 2025 China Association for Science and Technology. All rights reserved. For all open access content, the relevant licensing terms apply.
Sponsored by the Office of the Leading Group for Cybersecurity and Informatization of CAST, and supported by Science and Technology Review Publishing House